Peng Qianyu, Zhang Yuchan, Yang Shengfei, Yuwen Tianyi, Liu Yangkun, Fan Jingchuan, Zang Guangchao
Institute of Life Science, And Laboratory of Tissue and Cell Biology, Lab Teaching & Management Center, Chongqing Medical University, Chongqing, 400016, China.
Institute of Life Science, And Laboratory of Tissue and Cell Biology, Lab Teaching & Management Center, Chongqing Medical University, Chongqing, 400016, China.
Anal Chim Acta. 2021 May 15;1159:338442. doi: 10.1016/j.aca.2021.338442. Epub 2021 Mar 23.
Despite numerous advances in the field of nonenzymatic glucose detection, monitoring glucose in physiological applications is still a challenge and is mostly limited to electrode surface modification. This study proposes a simple method for electrodepositing cotton-like gold microspheres (CGMs) on a carbon cloth (CC) flexible electrode, with the potential for the functional supporting substrate to monitor glucose in a neutral environment. It was demonstrated that the voltammetric response of glucose oxidation increased with increases in glucose concentration in the 3D functional flexible substrate; moreover, the amperometric response of glucose oxidation increased over time. The results indicate that the functional flexible electrode-made of gold microspheres-based carbon cloth with a predefined geometry and pore-architecture network to promote the medium-permeation and synergetic effects between CGMs and CC-can be a suitable platform for measuring glucose variation in environments with neutral pH. This is particularly relevant because the oxygen-containing functional groups on the CC surface increase the dehydrogenation rate of glucose oxidation in neutral phosphate-buffered saline.
尽管在非酶葡萄糖检测领域取得了诸多进展，但在生理应用中监测葡萄糖仍然是一项挑战，并且大多局限于电极表面修饰。本研究提出了一种在碳布（CC）柔性电极上电沉积棉状金微球（CGM）的简单方法，该功能性支撑底物有潜力在中性环境中监测葡萄糖。结果表明，在三维功能性柔性底物中，葡萄糖氧化的伏安响应随葡萄糖浓度的增加而增强；此外，葡萄糖氧化的安培响应随时间增加。结果表明，由具有预定义几何形状和孔结构网络的金微球基碳布制成的功能性柔性电极，可促进介质渗透以及CGM与CC之间的协同效应，能够成为在中性pH环境中测量葡萄糖变化的合适平台。这一点尤为重要，因为CC表面的含氧官能团提高了中性磷酸盐缓冲盐水中葡萄糖氧化的脱氢速率。
