Institute of Life Science, and Laboratory of Tissue and Cell Biology, Lab Teaching & Management Center, Chongqing Medical University, Chongqing, 400016, China.
Chongqing Institute for Food and Drug Control, Chongqing, 401121, China.
J Nanobiotechnology. 2023 Sep 7;21(1):320. doi: 10.1186/s12951-023-02088-7.
The utilization of nanomaterials in the biosensor field has garnered substantial attention in recent years. Initially, the emphasis was on enhancing the sensor current rather than material interactions. However, carbon nanotubes (CNTs) have gained prominence in glucose sensors due to their high aspect ratio, remarkable chemical stability, and notable optical and electronic attributes. The diverse nanostructures and metal surface designs of CNTs, coupled with their exceptional physical and chemical properties, have led to diverse applications in electrochemical glucose sensor research. Substantial progress has been achieved, particularly in constructing flexible interfaces based on CNTs. This review focuses on CNT-based sensor design, manufacturing advancements, material synergy effects, and minimally invasive/noninvasive glucose monitoring devices. The review also discusses the trend toward simultaneous detection of multiple markers in glucose sensors and the pivotal role played by CNTs in this trend. Furthermore, the latest applications of CNTs in electrochemical glucose sensors are explored, accompanied by an overview of the current status, challenges, and future prospects of CNT-based sensors and their potential applications.
近年来，纳米材料在生物传感器领域的应用引起了广泛关注。最初，重点是提高传感器电流，而不是材料相互作用。然而，由于其高纵横比、显著的化学稳定性以及显著的光学和电子特性，碳纳米管 (CNT) 在葡萄糖传感器中脱颖而出。CNT 的多种纳米结构和金属表面设计，以及它们出色的物理和化学特性，导致它们在电化学葡萄糖传感器研究中有多种应用。已经取得了重大进展，特别是在构建基于 CNT 的柔性接口方面。本综述重点介绍基于 CNT 的传感器设计、制造进展、材料协同效应以及微创/非侵入性葡萄糖监测设备。该综述还讨论了同时检测葡萄糖传感器中多个标记物的趋势，以及 CNT 在这一趋势中所起的关键作用。此外，还探讨了 CNT 在电化学葡萄糖传感器中的最新应用，并概述了基于 CNT 的传感器的现状、挑战和未来前景及其潜在应用。
