Department of Dermatology, the Warren Alpert Medical School of Brown University, Providence, RI; and.
Center for Dermatoepidemiology, Veterans Affairs Medical Center, Providence, RI.
Am J Dermatopathol. 2021 Sep 1;43(9):647-652. doi: 10.1097/DAD.0000000000001852.
Eccrine porocarcinoma (EPC) is a rare sweat gland malignancy. Recognition of histologic features is challenging, and specific pathologic features correlate with risk of poor outcome. This single-center retrospective review and case series of 58 EPC cases from 2000 to 2016 elucidates epidemiologic and pathologic characteristics of EPC. Pathology slides from 52 cases were analyzed by a dermatopathologist for standardized variable characteristics, including previously determined high-risk features (HRF) associated with poor prognosis. The incidence of EPC increased over the study period with 3 times more cases diagnosed in the last 4 years than in the first 4 years. Most cases were in the elderly males (mean age 75 years), and 50% were located in the head and neck region. Although 38% of tumors exhibited one histologic HRF, only 10% exhibited more than one. Of the HRF, a greater tumor depth was associated with both increased age (P = 0.04) and clear cell differentiation (P = 0.02). This study elucidates epidemiologic and pathologic features of EPC and highlights how age and clear cell differentiation can be associated with greater tumor depth, although further research is needed to determine whether clear cell differentiation is associated with poor clinical outcome.
汗管癌（EPC）是一种罕见的汗腺恶性肿瘤。识别组织学特征具有挑战性，并且特定的病理特征与不良预后的风险相关。本研究回顾性分析了 2000 年至 2016 年间来自单一中心的 58 例 EPC 病例，阐明了 EPC 的流行病学和病理特征。由一名皮肤科病理学家对 52 例病例的病理切片进行了分析，以确定标准化的变量特征，包括先前确定的与预后不良相关的高危特征（HRF）。在研究期间，EPC 的发病率增加，最后 4 年诊断的病例是前 4 年的 3 倍。大多数病例发生在老年男性（平均年龄 75 岁），50%位于头颈部。尽管 38%的肿瘤存在一种组织学 HRF，但只有 10%的肿瘤存在多种 HRF。在 HRF 中，肿瘤深度越大与年龄增加（P=0.04）和透明细胞分化（P=0.02）有关。本研究阐明了 EPC 的流行病学和病理特征，并强调了年龄和透明细胞分化如何与更大的肿瘤深度相关，尽管需要进一步的研究来确定透明细胞分化是否与不良的临床结局相关。
