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4 月龄雄性完整混种伯恩山犬疑似原发性纯红细胞再生障碍。

Suspected primary pure red cell aplasia in a 4-month-old intact male mixed breed Bernese mountain dog.

机构信息

VCA Canada 404 Veterinary Emergency and Referral Hospital, 510 Harry Walker Parkway South, Newmarket, Ontario L3Y 0B3.

出版信息

Can Vet J. 2021 Apr;62(4):408-412.

PMID:33867556
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7953937/
Abstract

A 4-month-old, 31-kg intact male mixed-breed Bernese mountain dog was presented for evaluation of severe non-regenerative anemia after several days of lethargy, inappetence and pale mucous membranes. Bone marrow evaluation and complete response to immunosuppressive therapy were suggestive of primary pure red cell aplasia (PRCA). Primary PRCA is a rare immune-mediated non-regenerative anemia that is overrepresented in middle-aged to older spayed female dogs and has not previously been described in an intact male puppy.

摘要

一只 4 个月大、31 公斤重的雄性完整伯恩山犬,因数天嗜睡、食欲不振和黏膜苍白而被评估严重的非再生性贫血。骨髓评估和对免疫抑制治疗的完全反应提示原发性纯红细胞再生障碍(PRCA)。原发性 PRCA 是一种罕见的免疫介导的非再生性贫血,在中年至老年绝育雌性犬中发病率较高,以前从未在未绝育的雄性幼犬中描述过。

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本文引用的文献

1
Relationship between cobalamin and folate deficiencies and anemia in dogs.钴胺素和叶酸缺乏与犬类贫血之间的关系。
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The Use of Darbepoetin to Stimulate Erythropoiesis in the Treatment of Anemia of Chronic Kidney Disease in Dogs.使用达比泊汀刺激红细胞生成以治疗犬慢性肾病贫血
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Pure red cell aplasia.纯红细胞再生障碍。
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Oral Cobalamin Supplementation in Dogs with Chronic Enteropathies and Hypocobalaminemia.慢性肠病和低钴胺血症犬口服钴胺素补充治疗
J Vet Intern Med. 2016 Jan-Feb;30(1):101-7. doi: 10.1111/jvim.13797. Epub 2015 Dec 9.
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Automated analysis of bone marrow aspirates from dogs with haematological disorders.对患有血液系统疾病的犬类骨髓穿刺液进行自动分析。
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Selective intestinal cobalamin malabsorption with proteinuria (Imerslund-Gräsbeck syndrome) in juvenile Beagles.幼年比格犬的选择性肠道钴胺素吸收不良伴蛋白尿(Imerslund-Gräsbeck综合征)
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Cobalamin deficiency: clinical picture and radiological findings.钴胺素缺乏:临床表现和影像学表现。
Nutrients. 2013 Nov 15;5(11):4521-39. doi: 10.3390/nu5114521.
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Deceptive HbA₁c in a patient with pure red cell aplasia.纯红细胞再生障碍性贫血患者中出现的假性糖化血红蛋白。
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10
A frameshift mutation in the cubilin gene (CUBN) in Border Collies with Imerslund-Gräsbeck syndrome (selective cobalamin malabsorption).牧羊犬患 Imerslund-Gräsbeck 综合征(选择性钴胺素吸收不良)时,其穹窿蛋白基因(CUBN)发生移码突变。
PLoS One. 2013 Apr 16;8(4):e61144. doi: 10.1371/journal.pone.0061144. Print 2013.