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SeBioGraph:通过可持续知识转移实现的图的半监督深度学习

SeBioGraph: Semi-supervised Deep Learning for the Graph via Sustainable Knowledge Transfer.

作者信息

Ma Yugang, Li Qing, Hu Nan, Li Lili

机构信息

School of Architecture and Urban Planning, Chongqing University, Chongqing, China.

School of Computer Science, Northwestern Polytechnical University, Shaanxi, China.

出版信息

Front Neurorobot. 2021 Apr 1;15:665055. doi: 10.3389/fnbot.2021.665055. eCollection 2021.

DOI:10.3389/fnbot.2021.665055
PMID:33867966
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8047129/
Abstract

Semi-supervised deep learning for the biomedical graph and advanced manufacturing graph is rapidly becoming an important topic in both academia and industry. Many existing types of research focus on semi-supervised link prediction and node classification, as well as the application of these methods in sustainable development and advanced manufacturing. To date, most manufacturing graph neural networks are mainly evaluated on social and information networks, which improve the quality of network representation y integrating neighbor node descriptions. However, previous methods have not yet been comprehensively studied on biomedical networks. Traditional techniques fail to achieve satisfying results, especially when labeled nodes are deficient in number. In this paper, a new semi-supervised deep learning method for the biomedical graph via sustainable knowledge transfer called SeBioGraph is proposed. In SeBioGraph, both node embedding and graph-specific prototype embedding are utilized as transferable metric space characterized. By incorporating prior knowledge learned from auxiliary graphs, SeBioGraph further promotes the performance of the target graph. Experimental results on the two-class node classification tasks and three-class link prediction tasks demonstrate that the SeBioGraph realizes state-of-the-art results. Finally, the method is thoroughly evaluated.

摘要

用于生物医学图谱和先进制造图谱的半监督深度学习正迅速成为学术界和工业界的一个重要话题。许多现有类型的研究集中在半监督链接预测和节点分类,以及这些方法在可持续发展和先进制造中的应用。迄今为止,大多数制造图神经网络主要在社交和信息网络上进行评估,通过整合邻居节点描述来提高网络表示的质量。然而,以前的方法尚未在生物医学网络上进行全面研究。传统技术无法取得令人满意的结果,尤其是在标记节点数量不足时。本文提出了一种通过可持续知识转移用于生物医学图谱的新的半监督深度学习方法,称为SeBioGraph。在SeBioGraph中,节点嵌入和特定于图的原型嵌入都被用作可转移的度量空间特征。通过纳入从辅助图中学到的先验知识,SeBioGraph进一步提升了目标图的性能。在二分类节点分类任务和三分类链接预测任务上的实验结果表明,SeBioGraph实现了当前最优的结果。最后,对该方法进行了全面评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b26c/8047129/eb946cdd6894/fnbot-15-665055-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b26c/8047129/eb946cdd6894/fnbot-15-665055-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b26c/8047129/eb946cdd6894/fnbot-15-665055-g0001.jpg

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本文引用的文献

1
Predicting Drug-Target Interactions With Multi-Label Classification and Label Partitioning.利用多标签分类和标签分割预测药物-靶标相互作用。
IEEE/ACM Trans Comput Biol Bioinform. 2021 Jul-Aug;18(4):1596-1607. doi: 10.1109/TCBB.2019.2951378. Epub 2021 Aug 6.
2
Manifold regularized matrix factorization for drug-drug interaction prediction.多流正则化矩阵分解在药物-药物相互作用预测中的应用。
J Biomed Inform. 2018 Dec;88:90-97. doi: 10.1016/j.jbi.2018.11.005. Epub 2018 Nov 13.
3
The Comparative Toxicogenomics Database: update 2019.
比较毒理学基因组学数据库:2019 年更新。
Nucleic Acids Res. 2019 Jan 8;47(D1):D948-D954. doi: 10.1093/nar/gky868.
4
Modeling polypharmacy side effects with graph convolutional networks.基于图卷积网络的药物滥用副作用建模。
Bioinformatics. 2018 Jul 1;34(13):i457-i466. doi: 10.1093/bioinformatics/bty294.
5
Predicting drug-disease associations by using similarity constrained matrix factorization.基于相似性约束矩阵分解预测药物-疾病关联。
BMC Bioinformatics. 2018 Jun 19;19(1):233. doi: 10.1186/s12859-018-2220-4.
6
deepNF: deep network fusion for protein function prediction.深度网络融合的蛋白质功能预测。
Bioinformatics. 2018 Nov 15;34(22):3873-3881. doi: 10.1093/bioinformatics/bty440.
7
DrugBank 5.0: a major update to the DrugBank database for 2018.DrugBank 5.0:2018 年 DrugBank 数据库的重大更新。
Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
8
DeepGO: predicting protein functions from sequence and interactions using a deep ontology-aware classifier.DeepGO:使用深度本体感知分类器从序列和相互作用预测蛋白质功能。
Bioinformatics. 2018 Feb 15;34(4):660-668. doi: 10.1093/bioinformatics/btx624.
9
Predicting multicellular function through multi-layer tissue networks.通过多层组织网络预测多细胞功能。
Bioinformatics. 2017 Jul 15;33(14):i190-i198. doi: 10.1093/bioinformatics/btx252.
10
Predicting protein-protein interactions from protein sequences by a stacked sparse autoencoder deep neural network.通过堆叠式稀疏自动编码器深度神经网络从蛋白质序列预测蛋白质-蛋白质相互作用。
Mol Biosyst. 2017 Jun 27;13(7):1336-1344. doi: 10.1039/c7mb00188f.