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肺癌中 hepcidin 的上调：与免疫浸润相关的潜在治疗靶点。

Hepcidin Upregulation in Lung Cancer: A Potential Therapeutic Target Associated With Immune Infiltration.

机构信息

Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang, China.

Department of Neurosurgery, HanDan Central Hospital, Handan, China.

出版信息

Front Immunol. 2021 Apr 1;12:612144. doi: 10.3389/fimmu.2021.612144. eCollection 2021.

DOI:10.3389/fimmu.2021.612144
PMID:33868231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8047218/
Abstract

Lung cancer has the highest death rate among cancers globally. Hepcidin is a fascinating regulator of iron metabolism; however, the prognostic value of hepcidin and its correlation with immune cell infiltration in lung cancer remain unclear. Here, we comprehensively clarified the prognostic value and potential function of hepcidin in lung cancer. Hepcidin expression was significantly increased in lung cancer. High hepcidin expression was associated with sex, age, metastasis, and pathological stage and significantly predicted an unfavorable prognosis in lung cancer patients. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Enrichment Analysis (GSEA) results suggested that hepcidin is involved in the immune response. Furthermore, hepcidin expression was positively correlated with the infiltration levels of immune cells and the expression of diverse immune cell marker sets. Importantly, hepcidin may affect prognosis partially by regulating immune infiltration in lung cancer patients. Hepcidin may serve as a candidate prognostic biomarker for determining prognosis associated with immune infiltration in lung cancer.

摘要

肺癌是全球癌症死亡率最高的癌症。铁调素是铁代谢的一个迷人调节剂；然而，铁调素的预后价值及其与肺癌免疫细胞浸润的相关性尚不清楚。在这里，我们全面阐明了铁调素在肺癌中的预后价值和潜在功能。铁调素在肺癌中表达显著增加。高铁调素表达与性别、年龄、转移和病理分期有关，并显著预测肺癌患者预后不良。基因本体论（GO）、京都基因与基因组百科全书（KEGG）和基因集富集分析（GSEA）结果表明铁调素参与免疫反应。此外，铁调素的表达与免疫细胞浸润水平以及不同免疫细胞标志物集的表达呈正相关。重要的是，铁调素可能通过调节肺癌患者的免疫浸润来部分影响预后。铁调素可以作为一个候选预后生物标志物，用于确定与肺癌免疫浸润相关的预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/eab8f07ab65c/fimmu-12-612144-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/09ff6a3937ee/fimmu-12-612144-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/260944e7a1f8/fimmu-12-612144-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/9da9a34c99d2/fimmu-12-612144-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/f9dcdb8a9d82/fimmu-12-612144-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/3a95ec49748b/fimmu-12-612144-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/4c4c5b48f0a6/fimmu-12-612144-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/2cd3b8d79cc9/fimmu-12-612144-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/eab8f07ab65c/fimmu-12-612144-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/09ff6a3937ee/fimmu-12-612144-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/260944e7a1f8/fimmu-12-612144-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/9da9a34c99d2/fimmu-12-612144-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/f9dcdb8a9d82/fimmu-12-612144-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/3a95ec49748b/fimmu-12-612144-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/4c4c5b48f0a6/fimmu-12-612144-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/2cd3b8d79cc9/fimmu-12-612144-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76b4/8047218/eab8f07ab65c/fimmu-12-612144-g008.jpg

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