Biochemistry Department, Pasteur Institute of Iran, Tehran, 1963737611, Iran.
Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, 1416753955, Iran.
Pathog Dis. 2024 Feb 7;82. doi: 10.1093/femspd/ftae005.
There is a proven role for hepcidin and the composition of gut microbiota and its derivatives in the pathophysiology of liver fibrosis.
This review focuses on the literature search regarding the effect of hepcidin and gut microbiota on regulating liver physiology. We presented the regulating mechanisms of hepcidin expression and discussed the possible interaction between gut microbiota and hepcidin regulation. Furthermore, we investigated the importance of the hepcidin gene in biological processes and bacterial interactions using bioinformatics analysis.
One of the main features of liver fibrosis is iron accumulation in hepatic cells, including hepatocytes. This accumulation can induce an oxidative stress response, inflammation, and activation of hepatic stellate cells. Hepcidin is a crucial regulator of iron by targeting ferroportin expressed on hepatocytes, macrophages, and enterocytes. Various stimuli, such as iron load and inflammatory signals, control hepcidin regulation. Furthermore, a bidirectional relationship exists between iron and the composition and metabolic activity of gut microbiota. We explored the potential of gut microbiota to influence hepcidin expression and potentially manage liver fibrosis, as the regulation of iron metabolism plays a crucial role in this context.
铁调素和肠道微生物群及其衍生物在肝纤维化的病理生理学中具有明确的作用。
这篇综述重点关注了关于铁调素和肠道微生物群对调节肝脏生理的文献检索。我们介绍了铁调素表达的调节机制，并讨论了肠道微生物群和铁调素调节之间可能存在的相互作用。此外，我们使用生物信息学分析研究了铁调素基因在生物学过程和细菌相互作用中的重要性。
肝纤维化的主要特征之一是肝细胞（包括肝细胞）中铁的积累。这种积累会引起氧化应激反应、炎症和肝星状细胞的激活。铁调素是通过靶向肝细胞、巨噬细胞和肠细胞表达的亚铁转运蛋白来调节铁的关键调节剂。各种刺激物，如铁负荷和炎症信号，控制铁调素的调节。此外，铁和肠道微生物群的组成和代谢活性之间存在双向关系。我们探讨了肠道微生物群影响铁调素表达并可能管理肝纤维化的潜力，因为铁代谢的调节在这种情况下起着关键作用。
