Xia Haoming, Huang Ziyue, Liu Shuqiang, Zhao Xudong, He Risheng, Wang Zhongrui, Shi Wenguang, Chen Wangming, Li Zhizhou, Yu Liang, Huang Peng, Kang Pengcheng, Su Zhilei, Xu Yi, Yam Judy Wai Ping, Cui Yunfu
Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, China.
Front Oncol. 2021 Mar 26;11:653846. doi: 10.3389/fonc.2021.653846. eCollection 2021.
Exosomes are small extracellular vesicles secreted by most somatic cells, which can carry a variety of biologically active substances to participate in intercellular communication and regulate the pathophysiological process of recipient cells. Recent studies have confirmed that non-coding RNAs (ncRNAs) carried by tumor cell/non-tumor cell-derived exosomes have the function of regulating the cancerous derivation of target cells and remodeling the tumor microenvironment (TME). In addition, due to the unique low immunogenicity and high stability, exosomes can be used as natural vehicles for the delivery of therapeutic ncRNAs . This article aims to review the potential regulatory mechanism and the therapeutic value of exosomal ncRNAs in hepatocellular carcinoma (HCC), in order to provide promising targets for early diagnosis and precise therapy of HCC.
外泌体是大多数体细胞分泌的小细胞外囊泡，可携带多种生物活性物质参与细胞间通讯并调节受体细胞的病理生理过程。最近的研究证实，肿瘤细胞/非肿瘤细胞来源的外泌体携带的非编码RNA（ncRNA）具有调节靶细胞癌变和重塑肿瘤微环境（TME）的功能。此外，由于外泌体具有独特的低免疫原性和高稳定性，可作为治疗性ncRNA的天然载体。本文旨在综述外泌体ncRNA在肝细胞癌（HCC）中的潜在调控机制和治疗价值，为HCC的早期诊断和精准治疗提供有前景的靶点。
