• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

LINC01977通过靶向miR-212-3p/GOLM1轴促进乳腺癌进展及对多柔比星的化疗耐药性。

LINC01977 Promotes Breast Cancer Progression and Chemoresistance to Doxorubicin by Targeting miR-212-3p/GOLM1 Axis.

作者信息

Li Zheng, Li Yaming, Wang Xiaolong, Liang Yiran, Luo Dan, Han Dianwen, Li Chen, Chen Tong, Zhang Hanwen, Liu Ying, Wang Zekun, Chen Bing, Wang Lijuan, Zhao Wenjing, Yang Qifeng

机构信息

Department of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, China.

Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, China.

出版信息

Front Oncol. 2021 Mar 31;11:657094. doi: 10.3389/fonc.2021.657094. eCollection 2021.

DOI:10.3389/fonc.2021.657094
PMID:33869063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8046671/
Abstract

Long non-coding RNAs(lncRNAs) play an important role in cancer initiation and progression. However, hub lncRNAs involved in breast cancer still remain underexplored. In this study, integrated bioinformatics analysis was used to define LINC01977 as a key oncogenic driver in breast cancer. Subsequently, assays showed that LINC01977 could significantly promote breast cancer progression and chemoresistance to doxorubicin. To further investigate its biological mechanism, we performed dual-luciferase reporter assay, real-time PCR, RNA immunoprecipitation (RIP), and rescue assay. Our results indicated that LINC01977 may function as ceRNA to prevent GOLM1 gene from miRNA-mediated repression by sponging miR-212-3p. Overall, LINC01977 can serve as a novel prognostic indicator, and help develop more effective therapeutic approaches for breast cancer patients.

摘要

长链非编码RNA（lncRNAs）在癌症的发生和发展中起着重要作用。然而，参与乳腺癌的关键lncRNAs仍未得到充分研究。在本研究中，通过综合生物信息学分析将LINC01977定义为乳腺癌中的关键致癌驱动因子。随后的实验表明，LINC01977可显著促进乳腺癌进展以及对阿霉素的化疗耐药性。为进一步探究其生物学机制，我们进行了双荧光素酶报告基因检测、实时定量PCR、RNA免疫沉淀（RIP）及挽救实验。我们的结果表明，LINC01977可能作为竞争性内源RNA（ceRNA），通过结合miR-212-3p来阻止GOLM1基因受到miRNA介导的抑制作用。总体而言，LINC01977可作为一种新的预后指标，并有助于为乳腺癌患者开发更有效的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8879/8046671/4942e1ffe592/fonc-11-657094-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8879/8046671/2bc56476ab0d/fonc-11-657094-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8879/8046671/c1be7374a4c8/fonc-11-657094-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8879/8046671/9b524d969dfc/fonc-11-657094-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8879/8046671/55ef95759fa9/fonc-11-657094-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8879/8046671/6004fb925723/fonc-11-657094-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8879/8046671/4942e1ffe592/fonc-11-657094-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8879/8046671/2bc56476ab0d/fonc-11-657094-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8879/8046671/c1be7374a4c8/fonc-11-657094-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8879/8046671/9b524d969dfc/fonc-11-657094-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8879/8046671/55ef95759fa9/fonc-11-657094-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8879/8046671/6004fb925723/fonc-11-657094-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8879/8046671/4942e1ffe592/fonc-11-657094-g006.jpg

相似文献

1
LINC01977 Promotes Breast Cancer Progression and Chemoresistance to Doxorubicin by Targeting miR-212-3p/GOLM1 Axis.LINC01977通过靶向miR-212-3p/GOLM1轴促进乳腺癌进展及对多柔比星的化疗耐药性。
Front Oncol. 2021 Mar 31;11:657094. doi: 10.3389/fonc.2021.657094. eCollection 2021.
2
LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway.LINC01133 通过海绵吸附 miR-106a-3p 来抑制胃癌进展，从而调节 APC 表达和 Wnt/β-catenin 通路。
Mol Cancer. 2018 Aug 22;17(1):126. doi: 10.1186/s12943-018-0874-1.
3
LncRNA NORAD accelerates the progression and doxorubicin resistance of neuroblastoma through up-regulating HDAC8 via sponging miR-144-3p.长链非编码 RNA NORAD 通过海绵吸附 miR-144-3p 而上调 HDAC8 加速神经母细胞瘤的进展和多柔比星耐药性。
Biomed Pharmacother. 2020 Sep;129:110268. doi: 10.1016/j.biopha.2020.110268. Epub 2020 Jun 17.
4
Knockdown of Long Noncoding RNA HOXA-AS2 Suppresses Chemoresistance of Acute Myeloid Leukemia via the miR-520c-3p/S100A4 Axis.长链非编码RNA HOXA-AS2的敲低通过miR-520c-3p/S100A4轴抑制急性髓系白血病的化疗耐药性。
Cell Physiol Biochem. 2018;51(2):886-896. doi: 10.1159/000495387. Epub 2018 Nov 22.
5
LINC00673 is activated by YY1 and promotes the proliferation of breast cancer cells via the miR-515-5p/MARK4/Hippo signaling pathway.LINC00673 被 YY1 激活，并通过 miR-515-5p/MARK4/Hippo 信号通路促进乳腺癌细胞的增殖。
J Exp Clin Cancer Res. 2019 Oct 17;38(1):418. doi: 10.1186/s13046-019-1421-7.
6
Long noncoding RNA Linc00339 promotes triple-negative breast cancer progression through miR-377-3p/HOXC6 signaling pathway.长链非编码 RNA Linc00339 通过 miR-377-3p/HOXC6 信号通路促进三阴性乳腺癌的进展。
J Cell Physiol. 2019 Aug;234(8):13303-13317. doi: 10.1002/jcp.28007. Epub 2019 Jan 7.
7
CXCL12/CXCR4 promotes inflammation-driven colorectal cancer progression through activation of RhoA signaling by sponging miR-133a-3p.CXCL12/CXCR4 通过海绵吸附 miR-133a-3p 激活 RhoA 信号促进炎症驱动的结直肠癌进展。
J Exp Clin Cancer Res. 2019 Jan 24;38(1):32. doi: 10.1186/s13046-018-1014-x.
8
LINC00992 contributes to the oncogenic phenotypes in prostate cancer via targeting miR-3935 and augmenting GOLM1 expression.LINC00992 通过靶向 miR-3935 并增强 GOLM1 表达促进前列腺癌的致癌表型。
BMC Cancer. 2020 Aug 11;20(1):749. doi: 10.1186/s12885-020-07141-4.
9
HOXA-AS2 Promotes Proliferation and Induces Epithelial-Mesenchymal Transition via the miR-520c-3p/GPC3 Axis in Hepatocellular Carcinoma.HOXA-AS2通过miR-520c-3p/GPC3轴促进肝癌细胞增殖并诱导上皮-间质转化
Cell Physiol Biochem. 2018;50(6):2124-2138. doi: 10.1159/000495056. Epub 2018 Nov 9.
10
Long Non-coding RNA HOTTIP Promotes CCL3 Expression and Induces Cartilage Degradation by Sponging miR-455-3p.长链非编码RNA HOTTIP通过吸附miR-455-3p促进CCL3表达并诱导软骨降解。
Front Cell Dev Biol. 2019 Aug 23;7:161. doi: 10.3389/fcell.2019.00161. eCollection 2019.

引用本文的文献

1
Integrating Single-Cell and Spatial Transcriptomics to Uncover and Elucidate GP73-Mediated Pro-Angiogenic Regulatory Networks in Hepatocellular Carcinoma.整合单细胞和空间转录组学以揭示和阐明肝癌中GP73介导的促血管生成调控网络
Research (Wash D C). 2024 Jun 27;7:0387. doi: 10.34133/research.0387. eCollection 2024.
2
LINC01977 promotes colorectal cancer growth and metastasis by enhancing aerobic glycolysis via the ERK/c-Myc axis.LINC01977通过ERK/c-Myc轴增强有氧糖酵解促进结直肠癌的生长和转移。
J Gastrointest Oncol. 2024 Feb 29;15(1):271-285. doi: 10.21037/jgo-24-52. Epub 2024 Feb 28.
3
LncRNA MCM3AP-AS1 promotes chemoresistance in triple-negative breast cancer through the miR-524-5p/RBM39 axis.

本文引用的文献

1
PPP2R2B downregulation is associated with immune evasion and predicts poor clinical outcomes in triple-negative breast cancer.PPP2R2B下调与免疫逃逸相关，并预示三阴性乳腺癌的临床预后不良。
Cancer Cell Int. 2021 Jan 6;21(1):13. doi: 10.1186/s12935-020-01707-9.
2
Identification of a Six-Immune-Related Long Non-coding RNA Signature for Predicting Survival and Immune Infiltrating Status in Breast Cancer.用于预测乳腺癌生存及免疫浸润状态的六种免疫相关长链非编码RNA特征的鉴定
Front Genet. 2020 Jul 7;11:680. doi: 10.3389/fgene.2020.00680. eCollection 2020.
3
The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy.
长链非编码RNA MCM3AP-AS1通过miR-524-5p/RBM39轴促进三阴性乳腺癌的化疗耐药性。
Mol Cell Biochem. 2025 Jan;480(1):371-384. doi: 10.1007/s11010-023-04908-8. Epub 2024 Mar 12.
4
miRNAs as short non-coding RNAs in regulating doxorubicin resistance.微小RNA作为短链非编码RNA在调节阿霉素耐药性中的作用
J Cell Commun Signal. 2023 Dec;17(4):1181-1202. doi: 10.1007/s12079-023-00789-0. Epub 2023 Nov 29.
5
Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA.乳腺癌化疗耐药性：lncRNA 调控作用的新见解。
Int J Mol Sci. 2023 Nov 2;24(21):15897. doi: 10.3390/ijms242115897.
6
Insights into the involvement of long non-coding RNAs in doxorubicin resistance of cancer.长链非编码RNA参与癌症多柔比星耐药性的研究进展
Front Pharmacol. 2023 Sep 15;14:1243934. doi: 10.3389/fphar.2023.1243934. eCollection 2023.
7
Identification of lncRNAs Deregulated in Epithelial Ovarian Cancer Based on a Gene Expression Profiling Meta-Analysis.基于基因表达谱荟萃分析鉴定上皮性卵巢癌中失调的长链非编码 RNA。
Int J Mol Sci. 2023 Jun 28;24(13):10798. doi: 10.3390/ijms241310798.
8
Long Intergenic Non-Protein Coding RNA 173 in Human Cancers.人类癌症中的长链基因间非编码RNA 173
Cancers (Basel). 2022 Nov 30;14(23):5923. doi: 10.3390/cancers14235923.
9
LincRNAs and snoRNAs in Breast Cancer Cell Metastasis: The Unknown Players.乳腺癌细胞转移中的长链非编码RNA和小核仁RNA：未知因素
Cancers (Basel). 2022 Sep 19;14(18):4528. doi: 10.3390/cancers14184528.
10
Integration of miRNA:mRNA Co-Expression Revealed Crucial Mechanisms Modulated in Immunogenic Cancer Cell Death.miRNA与mRNA共表达的整合揭示了免疫原性癌细胞死亡中调控的关键机制。
Biomedicines. 2022 Aug 5;10(8):1896. doi: 10.3390/biomedicines10081896.
长链非编码 RNA H19 通过自噬促进乳腺癌对他莫昔芬的耐药性。
J Hematol Oncol. 2019 Jul 24;12(1):81. doi: 10.1186/s13045-019-0747-0.
4
Long noncoding RNA RP11-547D24.1 regulates proliferation and migration in papillary thyroid carcinoma: Identification and validation of a novel long noncoding RNA through integrated analysis of TCGA database.长非编码 RNA RP11-547D24.1 通过 TCGA 数据库的综合分析调节甲状腺乳头状癌的增殖和迁移：通过综合分析 TCGA 数据库鉴定和验证一种新型长非编码 RNA
Cancer Med. 2019 Jun;8(6):3105-3119. doi: 10.1002/cam4.2150. Epub 2019 May 1.
5
YAP1-induced MALAT1 promotes epithelial-mesenchymal transition and angiogenesis by sponging miR-126-5p in colorectal cancer.YAP1 诱导的 MALAT1 通过海绵吸附 miR-126-5p 促进结直肠癌细胞的上皮-间充质转化和血管生成。
Oncogene. 2019 Apr;38(14):2627-2644. doi: 10.1038/s41388-018-0628-y. Epub 2018 Dec 10.
6
The Long Noncoding RNA TTTY15, Which Is Located on the Y Chromosome, Promotes Prostate Cancer Progression by Sponging let-7.位于 Y 染色体上的长非编码 RNA TTTY15 通过海绵吸附 let-7 促进前列腺癌进展。
Eur Urol. 2019 Sep;76(3):315-326. doi: 10.1016/j.eururo.2018.11.012. Epub 2018 Dec 7.
7
The lncRNA BORG facilitates the survival and chemoresistance of triple-negative breast cancers.长链非编码 RNA BORG 促进三阴性乳腺癌的存活和化疗耐药性。
Oncogene. 2019 Mar;38(12):2020-2041. doi: 10.1038/s41388-018-0586-4. Epub 2018 Nov 22.
8
Linc00659, a long noncoding RNA, acts as novel oncogene in regulating cancer cell growth in colorectal cancer.Linc00659，一种长链非编码 RNA，作为一种新型癌基因在调控结直肠癌细胞生长中发挥作用。
Mol Cancer. 2018 Mar 10;17(1):72. doi: 10.1186/s12943-018-0821-1.
9
PDGFA/PDGFRα-regulated GOLM1 promotes human glioma progression through activation of AKT.PDGFA/PDGFRα 调控的 GOLM1 通过激活 AKT 促进人神经胶质瘤的进展。
J Exp Clin Cancer Res. 2017 Dec 28;36(1):193. doi: 10.1186/s13046-017-0665-3.
10
The Many Faces of Long Noncoding RNAs in Cancer.长链非编码 RNA 在癌症中的多面性。
Antioxid Redox Signal. 2018 Sep 20;29(9):922-935. doi: 10.1089/ars.2017.7293. Epub 2017 Oct 20.