长链非编码 RNA 在癌症中的多面性。
The Many Faces of Long Noncoding RNAs in Cancer.
机构信息
1 Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana.
2 Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, Indiana.
出版信息
Antioxid Redox Signal. 2018 Sep 20;29(9):922-935. doi: 10.1089/ars.2017.7293. Epub 2017 Oct 20.
SIGNIFICANCE
The emerging connections between an increasing number of long noncoding RNAs (lncRNAs) and oncogenic hallmarks provide a new twist to tumor complexity. Recent Advances: In the present review, we highlight specific lncRNAs that have been studied in relation to tumorigenesis, either as participants in the neoplastic process or as markers of pathway activity or drug response. These transcripts are typically deregulated by oncogenic or tumor-suppressing signals or respond to microenvironmental conditions such as hypoxia.
CRITICAL ISSUES
Among these transcripts are lncRNAs sufficiently divergent between mouse and human genomes that may contribute to biological differences between species.
FUTURE DIRECTIONS
From a translational standpoint, knowledge about primate-specific lncRNAs may help explain the reason behind the failure to reproduce the results from mouse cancer models in human cell-based systems. Antioxid. Redox Signal. 29, 922-935.
意义
越来越多的长非编码 RNA（lncRNA）与致癌标志之间的新兴联系为肿瘤的复杂性提供了一个新的视角。
最新进展
在本综述中，我们重点介绍了一些与肿瘤发生相关的特定 lncRNA，这些 lncRNA 要么作为肿瘤发生过程的参与者，要么作为通路活性或药物反应的标志物。这些转录本通常受到致癌或肿瘤抑制信号的调节，或者对缺氧等微环境条件作出反应。
关键问题
在这些转录本中，有一些 lncRNA 在小鼠和人类基因组之间差异很大，这可能有助于解释物种间生物学差异的原因。
未来方向
从转化的角度来看，关于灵长类动物特异性 lncRNA 的知识可能有助于解释为什么在基于人类细胞的系统中无法重现小鼠癌症模型的结果。
Zotero 插件