Wang Xia, He He, Zhang Mei, Li Chuan, Jia Chengyao
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Front Oncol. 2021 Mar 25;11:662169. doi: 10.3389/fonc.2021.662169. eCollection 2021.
Multiple myeloma (MM) is a neoplastic disorder characterized by clonal proliferation of malignant plasma cells derived from B cells in bone marrow. Pediatric MM is rare with only approximately 0.3% of cases diagnosed before the age of 30. In this report, we present a 14 years old boy diagnosed as MM with multiple pathologic vertebral fractures. To our knowledge, our patient is the youngest Chinese case in the literature to present with MM. He was treated with bortezomib, dexamethasone, and cyclophosphamide followed by autologous hematopoietic stem cell transplantation with good clinical response. We hope to aid in the understanding of the pathophysiology and management of this condition.
多发性骨髓瘤（MM）是一种肿瘤性疾病，其特征是骨髓中源自B细胞的恶性浆细胞发生克隆性增殖。儿童MM较为罕见，30岁之前诊断出的病例仅约0.3%。在本报告中，我们介绍了一名14岁被诊断为MM并伴有多发性病理性椎体骨折的男孩。据我们所知，我们的患者是文献中报道的最年轻的中国MM病例。他接受了硼替佐米、地塞米松和环磷酰胺治疗，随后进行了自体造血干细胞移植，临床反应良好。我们希望有助于增进对这种疾病的病理生理学和治疗的理解。
