Costa Santos Diogo, Lérias Graça, Madruga Isabel
Department of Internal Medicine, Egas Moniz Hospital, Lisbon, Portugal.
Eur J Case Rep Intern Med. 2021 Mar 16;8(3):002389. doi: 10.12890/2021_002389. eCollection 2021.
Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the Western world. In recent years, natural herbal and dietary supplements have become widely available to the general public and have increased in popularity. Reports of idiosyncratic liver injury caused by such supplements have also increased over the last decade. Horse chestnut is a herb used in dietary supplements primarily for complications of venous insufficiency. Clinically significant acute liver injury has been very rarely associated with its use. We present the case of a 70-year-old man with idiosyncratic horse chestnut-induced liver injury.
Idiosyncratic drug-induced liver injury is one of the most challenging liver disorders.Herbs and natural dietary supplements are widely popular and should be considered when evaluating liver injury of unknown origin.Patients may not consider herbs and supplements to be drugs with the potential to cause adverse effects, requiring a more careful medication history.
药物性肝损伤（DILI）是西方世界急性肝衰竭最常见的病因。近年来，天然草药和膳食补充剂已广泛供应给普通大众，且越来越受欢迎。在过去十年中，此类补充剂引起的特异质性肝损伤报告也有所增加。七叶树是一种主要用于治疗静脉功能不全并发症的膳食补充剂中的草药。临床上显著的急性肝损伤与其使用相关的情况非常罕见。我们报告一例70岁男性因七叶树引起的特异质性肝损伤病例。
特异质性药物性肝损伤是最具挑战性的肝脏疾病之一。草药和天然膳食补充剂广受欢迎，在评估不明原因的肝损伤时应予以考虑。患者可能不认为草药和补充剂是有潜在不良反应的药物，因此需要更仔细地询问用药史。
