Zou Juanjuan, Yang Yan, Fu Qiang, Liu Huayang, Zhang Chao, Liu Lili, Wang Yan, Li Yanzhong
Department of Otorhinolaryngology, Qilu Hospital of Shandong University, NHC Key Laboratory of Otorhinolaryngology (Shandong University), Jinan, China.
Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.
Front Pediatr. 2021 Mar 31;9:598063. doi: 10.3389/fped.2021.598063. eCollection 2021.
The relationship between eosinophils/basophils and allergic sensitization is not clear in pediatric adenotonsillar hypertrophy (ATH). The objective of this study is to investigate the relationship between eosinophil/basophil counts and peripheral specific IgE levels, and identify the common allergens in children with ATH. We initially screened 1,031 consecutive children who underwent adenotonsillectomy in our department from June 2018 to June 2019, and finally included 676 children. The eosinophil count, basophil count, and levels of specific IgE were collected. Correlations between two quantitative variables were assessed using the Pearson or Spearman coefficient. Logistic regression analyses were performed to evaluate the odds ratios (ORs) for atopy after controlling for age, sex, vitamin D, BMI, and visiting season. Both the eosinophil and basophil counts in atopic participants were significantly higher compared to non-atopic participants. The eosinophil count correlated with the levels of IgE specific to all allergens, and eosinophilia was independently associated with all tested atopy allergens other than atopy to dander after multivariate adjustment. Additionally, the basophil count correlated with the IgE levels specific to A. and food mix, and basophilia was still significantly associated with atopy to food mix after multivariable adjustment. Furthermore, among allergic participants, D. was the most prevalent allergen, followed by food mix, D. , and A. . In conclusion, eosinophils were more relevant to allergic sensitization than basophils, with eosinophils being significantly associated with all tested atopy allergens apart from dander, and basophils being associated with atopy to food mix. Furthermore, D. was the most prevalent allergen and may be indicative of desensitization therapy.
在小儿腺样体扁桃体肥大（ATH）中，嗜酸性粒细胞/嗜碱性粒细胞与过敏致敏之间的关系尚不清楚。本研究的目的是探讨嗜酸性粒细胞/嗜碱性粒细胞计数与外周血特异性IgE水平之间的关系，并确定ATH患儿中的常见变应原。我们最初筛选了2018年6月至2019年6月在我科连续接受腺样体扁桃体切除术的1031名儿童，最终纳入676名儿童。收集了嗜酸性粒细胞计数、嗜碱性粒细胞计数和特异性IgE水平。使用Pearson或Spearman系数评估两个定量变量之间的相关性。进行逻辑回归分析以评估在控制年龄、性别、维生素D、BMI和就诊季节后特应性的优势比（OR）。与非特应性参与者相比，特应性参与者的嗜酸性粒细胞和嗜碱性粒细胞计数均显著更高。嗜酸性粒细胞计数与所有变应原特异性IgE水平相关，并且在多变量调整后，除对皮屑的特应性外，嗜酸性粒细胞增多与所有测试的特应性变应原独立相关。此外，嗜碱性粒细胞计数与A.和食物混合物特异性IgE水平相关，并且在多变量调整后，嗜碱性粒细胞增多仍与对食物混合物的特应性显著相关。此外，在过敏参与者中，D.是最常见的变应原，其次是食物混合物、D.和A.。总之，嗜酸性粒细胞比嗜碱性粒细胞与过敏致敏更相关，嗜酸性粒细胞与除皮屑外的所有测试特应性变应原显著相关，而嗜碱性粒细胞与对食物混合物的特应性相关。此外，D.是最常见的变应原，可能提示脱敏治疗。
