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新型冠状病毒肺炎(COVID-19)严重程度与社会人口统计学及维生素D使用情况的关系

COVID-19 severity in relation to sociodemographics and vitamin D use.

作者信息

Abdulateef Darya Saeed, Rahman Heshu Sulaiman, Salih Jamal Mahmood, Osman Sangar Mahmoud, Mahmood Trifa Abdalla, Omer Shirwan Hama Salih, Ahmed Rana Adnan

机构信息

Department of Physiology, College of Medicine, University of Sulaimani, New-Street-27, Zone 209, P. O. Box: 334, Kurdistan Region, Sulaymaniyah, Iraq.

出版信息

Open Med (Wars). 2021 Apr 8;16(1):591-609. doi: 10.1515/med-2021-0273. eCollection 2021.

Abstract

Most COVID-19 cases are treated as outpatients, while the majority of studies on COVID-19 focus on inpatients. Little is known about the self-reporting and self-rating of the disease's symptoms, and the associations of prophylactic use of dietary supplements with COVID-19 severity have not been addressed. The aims of this study are to evaluate COVID-19 severity and to relate them to sociodemographic characteristics and prophylactic dietary supplements. An observational patient-based study conducted through an online questionnaire on recovered COVID-19 patients. The patients were assessed for several severity parameters, sociodemographic parameters, and prophylactic dietary supplement use. A total of 428 patients were evaluated. Age and presence of comorbidities had positive associations with the severity parameters. The severe infection group had the highest proportion of patients stressed about COVID-19 ( < 0.05). Cigarette, but not hookah, smoking was significantly associated with less severe symptoms. Vitamin D negatively predicted disease severity ( < 0.05). In conclusion, stress, age, and presence of comorbidities were the most important positive predictors of COVID-19 severity, while prophylactic vitamin D use and smoking were significant negative predictors. The use of protective measures and other prophylactic dietary supplements was not significantly associated with symptom severity.

摘要

大多数新冠病毒疾病(COVID-19)病例作为门诊患者接受治疗,而大多数关于COVID-19的研究集中在住院患者。对于该疾病症状的自我报告和自我评分了解甚少,并且预防性使用膳食补充剂与COVID-19严重程度之间的关联尚未得到探讨。本研究的目的是评估COVID-19的严重程度,并将其与社会人口统计学特征和预防性膳食补充剂相关联。通过对康复的COVID-19患者进行在线问卷调查开展了一项基于患者的观察性研究。对患者进行了多项严重程度参数、社会人口统计学参数和预防性膳食补充剂使用情况的评估。总共评估了428名患者。年龄和合并症的存在与严重程度参数呈正相关。重症感染组中对COVID-19感到压力的患者比例最高(<0.05)。吸烟(而非水烟)与症状较轻显著相关。维生素D对疾病严重程度具有负向预测作用(<0.05)。总之,压力、年龄和合并症的存在是COVID-19严重程度最重要的正向预测因素,而预防性使用维生素D和吸烟是显著的负向预测因素。使用防护措施和其他预防性膳食补充剂与症状严重程度无显著关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/8034240/4494cdbeb8d2/j_med-2021-0273-fig001.jpg

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