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在一家国家级癌症中心为身体机能减退的癌症幸存者实施运动计划的可行性:FIXCAS研究。

The feasibility of implementing an exercise programme for deconditioned cancer survivors in a national cancer centre: FIXCAS Study.

作者信息

Devenney Kate, Murphy Niamh, Ryan Ronan, Grant Clíona, Kennedy John, Manecksha Rustom P, Sheils Orla, McNeely Margaret L, Hussey Juliette, Sheill Grainne

机构信息

University of Dublin, Dublin, Ireland.

St. James's Hospital, Dublin, Dublin, Ireland.

出版信息

HRB Open Res. 2020 Dec 18;2:24. doi: 10.12688/hrbopenres.12925.2. eCollection 2019.

Abstract

As both the number of cancer survivors and the length of survival time are increasing, long-term health issues related to cancer and its treatment are becoming more prevalent. Research suggests that exercise can mitigate several negative health consequences in cancer survivors and improve physical function and quality of life. Multi-modal exercise interventions have been proposed as a cornerstone for survivorship care. However, studies evaluating exercise programmes within the Irish population are lacking. To evaluate the introduction, implementation and acceptability of a multi-modal exercise rehabilitation programme for deconditioned cancer survivors in a real-world, standard practice setting. In this single-arm prospective feasibility study, cancer survivors (n=40) will undergo a 10-week multi-modal exercise programme. The study population will comprise of cancer survivors attending outpatient services in an Irish national cancer centre. Participants will be aged 18 or older and have completed treatment with curative intent. Feasibility will be evaluated in terms of recruitment, adherence and compliance to the programme. Secondary outcomes will examine physical function and quality of life measures. In addition, the acceptability of the programme will be assessed through stakeholder feedback. : Ethical approval through the St. James's Hospital and Tallaght University Hospital Research and Ethics Committee is currently pending. The study results will be used to optimise the intervention content and may serve as the foundation for a larger definitive trial. Results will be disseminated through peer-review journals, congresses and relevant clinical groups. : ClinicalTrials.gov NCT04026659 (19/07/19).

摘要

随着癌症幸存者数量和生存时间的增加,与癌症及其治疗相关的长期健康问题日益普遍。研究表明,运动可以减轻癌症幸存者的一些负面健康后果,改善身体功能和生活质量。多模式运动干预已被提议作为生存护理的基石。然而,缺乏对爱尔兰人群运动项目的评估研究。为了评估在现实世界的标准实践环境中,针对身体状况不佳的癌症幸存者的多模式运动康复项目的引入、实施和可接受性。在这项单臂前瞻性可行性研究中,40名癌症幸存者将接受为期10周的多模式运动项目。研究人群将包括在爱尔兰国家癌症中心门诊就诊的癌症幸存者。参与者年龄在18岁及以上,并且已经完成了根治性治疗。将从招募、对项目的依从性和遵守情况方面评估可行性。次要结果将检查身体功能和生活质量指标。此外,将通过利益相关者的反馈来评估该项目的可接受性。:目前正在等待圣詹姆斯医院和塔拉赫特大学医院研究与伦理委员会的伦理批准。研究结果将用于优化干预内容,并可能作为更大规模确定性试验的基础。结果将通过同行评审期刊、大会和相关临床组进行传播。:ClinicalTrials.gov NCT04026659(2019年7月19日)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b3d/8030109/63a2610ece56/hrbopenres-2-14333-g0000.jpg

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