乳腺组织中的基因表达
Gene Expression in Breast Tissue.
作者信息
Al-Benna Sammy
机构信息
Division of Plastic and Reconstructive Surgery, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa.
出版信息
Eur J Breast Health. 2021 Mar 31;17(2):112-115. doi: 10.4274/ejbh.galenos.2021.6007. eCollection 2021 Apr.
OBJECTIVE
Binding to angiotensin-converting enzyme 2 (ACE2) receptor is a critical step for severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) to mediate its entry into target cells. ACE2 is expressed in many human tissues, including the lungs. However, no research has demonstrated that SARS-CoV-2 can infect human breast tissue. This study aimed to investigate gene expression in human breast tissue using a public database.
MATERIALS AND METHODS
A search of a public gene expression database was performed to investigate gene expression in in human breast tissue.
RESULTS
The gene expression profile demonstrated that gene expression was higher in human breast tissue than human lung tissue.
CONCLUSION
Our knowledge about coronavirus disease-2019 (COVID-19) is expanding rapidly. Clinicians are eager for vetted information regarding all aspects of this new illness, and this study demonstrates that the level of ACE2 expression in human breast tissue is higher than that in the lung tissue, a major target tissue affected by SARS-CoV-2 infection. This finding strongly suggests that SARS-CoV-2 infection causes breast pathology.
目的
与血管紧张素转换酶2（ACE2）受体结合是严重急性呼吸综合征冠状病毒2（SARS-CoV-2）介导其进入靶细胞的关键步骤。ACE2在包括肺在内的许多人体组织中表达。然而，尚无研究表明SARS-CoV-2可感染人类乳腺组织。本研究旨在利用公共数据库调查人类乳腺组织中的基因表达。
材料与方法
检索公共基因表达数据库以调查人类乳腺组织中的基因表达。
结果
基因表达谱显示，人类乳腺组织中的基因表达高于人类肺组织。
结论
我们对2019冠状病毒病（COVID-19）的了解正在迅速扩展。临床医生渴望获得有关这种新疾病各方面的经过审核的信息，并且本研究表明人类乳腺组织中ACE2的表达水平高于肺组织，肺组织是受SARS-CoV-2感染影响的主要靶组织。这一发现强烈表明SARS-CoV-2感染会导致乳腺病变。
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