High-dose dexamethasone and high-dose metoclopramide versus high-dose dexamethasone and sulpiride in the management of cisplatin-induced emesis.

Twenty-eight courses of combination chemotherapy including cisplatin at the dose of 50 mg/m2 were analyzed in this antiemetic randomized double-blind study. The combination of high-dose dexamethasone and high-dose metoclopramide (regimen A) was compared with the combination of high-dose dexamethasone and sulpiride (regimen B). Regimen A was found to be more effective than regimen B when the mean score for intensity of vomiting was presented in only two categories. Four patients (14.3%) treated with regimen A suffered neither from nausea nor from vomiting. No serious side effects were observed.