达托霉素诱导的嗜酸性肺炎：是否存在任何危险因素？
Daptomycin-induced eosinophilic pneumonia: Are there any risk factors?
机构信息
Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence Constitutif des maladies Pulmonaires rares de l'Adultes de Dijon, réseau OrphaLung, Filère RespiFil, Centre Hospitalier Universitaire de Bourgogne, 14, rue Paul-Gaffarel, 21000 Dijon, France.
Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence Constitutif des maladies Pulmonaires rares de l'Adultes de Dijon, réseau OrphaLung, Filère RespiFil, Centre Hospitalier Universitaire de Bourgogne, 14, rue Paul-Gaffarel, 21000 Dijon, France; Université de Bourgogne Franche-Comté, Faculté de médecine, Dijon, France; NSERM U123-1, Dijon, France.
出版信息
Infect Dis Now. 2021 Oct;51(7):618-621. doi: 10.1016/j.idnow.2021.01.002. Epub 2021 Jan 9.
OBJECTIVES
Daptomycin is a widely used antibiotic. Rhabdomyolysis related to daptomycin is one of the adverse effects of treatment, justifying the need for regular monitoring of muscle enzymes throughout treatment. Daptomycin may also lead to eosinophilic pneumonia. However, risk factors for this adverse reaction have not been identified and do not permit targeting of at-risk populations who could benefit from appropriate monitoring.
PATIENTS AND METHODS
Literature was reviewed for cases of daptomycin-induced eosinophilic pneumonia (DIEP), which that were compared to cases of patients without this adverse effect.
RESULTS
Fifty patients with DIEP and 54 controls were identified. Age, sex, and treatment dose are not associated with the occurrence of DIEP. A high dose of daptomycin is not associated with an early onset of DIEP. About one third of patients with eosinophilic lung disease have diabetes or renal impairment.
CONCLUSIONS
Further studies may help to identify additional factors.
目的
达托霉素是一种广泛使用的抗生素。达托霉素治疗相关的横纹肌溶解症是其治疗的不良反应之一，这证明了在整个治疗过程中需要定期监测肌肉酶。达托霉素也可能导致嗜酸性粒细胞性肺炎。然而，这种不良反应的危险因素尚未确定，无法针对可能受益于适当监测的高危人群进行靶向治疗。
患者和方法
对达托霉素诱导的嗜酸性粒细胞性肺炎（DIEP）的病例进行了文献回顾，并将其与无此不良反应的病例进行了比较。
结果
共确定了 50 例 DIEP 患者和 54 例对照患者。年龄、性别和治疗剂量与 DIEP 的发生无关。达托霉素高剂量与 DIEP 的早期发病无关。约三分之一的嗜酸性肺疾病患者患有糖尿病或肾功能损害。
结论
进一步的研究可能有助于确定其他因素。
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