Adipose-derived stem cell exosomes facilitate rotator cuff repair by mediating tendon-derived stem cells.

To evaluate the potential capability of adipose-derived stem cell exosomes (ADSC-exos) on rotator cuff repair by mediating the tendon-derived stem cells (TDSCs) and explored the mechanism. First, we investigated the growth, survival and migration of TDSCs in the presence of ADSC-exos . Using a rat rotator cuff injury model to analyze the ability of the ADSC-exos to promote rotator cuff healing . The hydrogel with ADSC-exos significantly improved the osteogenic and adipogenesis differentiation and enhanced the expression of , , ,  and  and the mechanical properties of the articular portion. The ADSC-exos have the potential to promote the rotator cuff repair by mediating the TDSCs.