Department of Organic Chemistry, University of Geneva, Geneva, Switzerland.
Chem Commun (Camb). 2021 Apr 25;57(32):3913-3916. doi: 10.1039/d1cc00860a. Epub 2021 Mar 23.
Despite their growing popularity in biology to image membrane tension, central design principles of flipper probes have never been validated. Here we report that upon deletion of their primary dipole, from electron-poor and electron-rich dithienothiophenes, absorptions blue-shift, lifetimes shorten dramatically, and mechanosensitivity in cells vanishes not partially, but completely.
尽管 flipper 探针在生物学中用于成像膜张力的应用越来越受欢迎，但它们的核心设计原则从未得到验证。在这里，我们报告说，当它们的主要偶极子从缺电子和富电子的二噻吩并噻吩中删除时，吸收会蓝移，寿命会显著缩短，而细胞中的机械敏感性不是部分消失，而是完全消失。
