Danon M, Velez O, Ostrea T, Crawford J D, Beitins I Z
Department of Pediatrics, Facultad de Medicina Universidad del Valle, Cali, Colombia.
Pediatr Res. 1988 May;23(5):530-3. doi: 10.1203/00006450-198805000-00019.
Serum luteinizing hormone-human chorionic gonadotropin bioactivity (B-LH) was measured daily in seven male and four female full-term newborns during the first 7 days of life. The B-LH levels were elevated in both sexes during the 1st day of life; subsequently, values decreased in both sexes. In males, they reached a nadir on the 4th day of life. A gradual secondary rise was then observed with B-LH levels on the 7th day significantly higher than on day 4 (p less than 0.025). By contrast, the B-LH levels in the females continued a gradual decline to levels significantly lower on day 7 as compared to day 4 (p less than 0.05). To determine whether pulsatile B-LH secretion occurs in newborns, serum concentrations were measured every 20 min for 2 h in eight male and seven female full-term neonates on the 7th day of life. Pulsatile secretion of B-LH was detected in six males and six females. This study demonstrates that pulsatility of gonadotropin secretion is characteristic of neonates as early as 7 days of life and that there is a dichotomy between the levels of B-LH in males and females; levels in females decline progressively from day 1 through 7, whereas in males, a nadir is reached on day 4 with a secondary rise developing thereafter. This male sex-specific rise is presumably the drive responsible for the characteristic postnatal increase in testosterone which peaks at 1 to 2 months of age.
在出生后的头7天里，每天对7名男婴和4名女婴进行血清促黄体生成素-人绒毛膜促性腺激素生物活性（B-LH）检测。在出生第1天，两性的B-LH水平均升高；随后，两性的数值均下降。在男婴中，出生第4天降至最低点。随后观察到逐渐的二次升高，第7天的B-LH水平显著高于第4天（p<0.025）。相比之下，女婴的B-LH水平持续逐渐下降，第7天的水平显著低于第4天（p<0.05）。为了确定新生儿是否存在促黄体生成素的脉冲式分泌，在出生第7天对8名男婴和7名女婴每20分钟测量一次血清浓度，持续2小时。在6名男婴和6名女婴中检测到促黄体生成素的脉冲式分泌。这项研究表明，促性腺激素分泌的脉冲性早在出生7天的新生儿中就有特征性表现，并且男性和女性的B-LH水平存在差异；女性的水平从出生第1天到第7天逐渐下降，而男性在第4天达到最低点，随后出现二次升高。这种男性特有的升高可能是出生后睾酮特征性升高的驱动力，睾酮在1至2个月大时达到峰值。
