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Plant-derived secretory component gives protease-resistance to Shiga toxin 1-specific dimeric IgA.

作者信息

Nakanishi Katsuhiro, Mogi Noriko, Kikuchi Yuki, Matsuda Minami, Matsuoka Takeshi, Shiina Kotome, Morikane Shota, Kurohane Kohta, Niwa Yasuo, Kobayashi Hirokazu, Imai Yasuyuki

机构信息

Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka City, Shizuoka, 422-8526, Japan.

Laboratory of Plant Molecular Improvement, Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka City, Shizuoka, 422-8526, Japan.

出版信息

Plant Mol Biol. 2021 Jun;106(3):297-308. doi: 10.1007/s11103-021-01151-x. Epub 2021 Apr 19.

DOI:10.1007/s11103-021-01151-x
PMID:33871797
Abstract
摘要

相似文献

1
Plant-derived secretory component gives protease-resistance to Shiga toxin 1-specific dimeric IgA.植物源分泌成分赋予抗志贺毒素1特异性二聚体IgA蛋白酶的能力。
Plant Mol Biol. 2021 Jun;106(3):297-308. doi: 10.1007/s11103-021-01151-x. Epub 2021 Apr 19.
2
Plant-derived secretory component forms secretory IgA with shiga toxin 1-specific dimeric IgA produced by mouse cells and whole plants.植物来源的分泌成分与小鼠细胞和整株植物产生的志贺毒素 1 特异性二聚体 IgA 形成分泌型 IgA。
Plant Cell Rep. 2019 Feb;38(2):161-172. doi: 10.1007/s00299-018-2358-6. Epub 2018 Nov 30.
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Lettuce-derived secretory IgA specifically neutralizes the Shiga toxin 1 activity.生菜来源的分泌型 IgA 特异性中和志贺毒素 1 的活性。
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Prevention of Shiga toxin 1-caused colon injury by plant-derived recombinant IgA.植物源重组 IgA 预防志贺毒素 1 引起的结肠损伤
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Stable expression and characterization of monomeric and dimeric recombinant hybrid-IgG/IgA immunoglobulins specific for Shiga toxin.针对志贺毒素的单体和二聚体重组杂交IgG/IgA免疫球蛋白的稳定表达及特性研究
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Shiga toxin-induced apoptosis is more efficiently inhibited by dimeric recombinant hybrid-IgG/IgA immunoglobulins than by the parental IgG monoclonal antibodies.与亲本IgG单克隆抗体相比，二聚体重组杂交IgG/IgA免疫球蛋白能更有效地抑制志贺毒素诱导的细胞凋亡。
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Production of hybrid-IgG/IgA plantibodies with neutralizing activity against Shiga toxin 1.生产具有中和 Shiga 毒素 1 活性的杂交-IgG/IgA 植物抗体。
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Resistance of normal serum IgA and secretory IgA to bacterial IgA proteases: evidence for the presence of enzyme-neutralizing antibodies in both serum and secretory IgA, and also in serum IgG.正常血清IgA和分泌型IgA对细菌IgA蛋白酶的抗性：血清和分泌型IgA以及血清IgG中存在酶中和抗体的证据。
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Secretory component delays the conversion of secretory IgA into antigen-binding competent F(ab')2: a possible implication for mucosal defense.分泌成分延缓分泌型IgA转化为具有抗原结合能力的F(ab')2：对黏膜防御的可能影响。
J Immunol. 1998 Nov 15;161(10):5445-53.
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Disulfide bonding of secretory component to a single monomer subunit in human secretory IgA.分泌成分与人分泌型IgA中单个单体亚基的二硫键结合。
J Immunol. 1977 May;118(5):1816-21.

引用本文的文献

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Prevention of Shiga toxin 1-caused colon injury by plant-derived recombinant IgA.植物源重组 IgA 预防志贺毒素 1 引起的结肠损伤
Sci Rep. 2022 Oct 26;12(1):17999. doi: 10.1038/s41598-022-22851-4.

本文引用的文献

1
Preformulation Characterization and Stability Assessments of Secretory IgA Monoclonal Antibodies as Potential Candidates for Passive Immunization by Oral Administration.分泌型免疫球蛋白 A 单克隆抗体的前配方特征和稳定性评估，作为口服被动免疫的潜在候选药物。
J Pharm Sci. 2020 Jan;109(1):407-421. doi: 10.1016/j.xphs.2019.07.018. Epub 2019 Jul 29.
2
Lettuce-derived secretory IgA specifically neutralizes the Shiga toxin 1 activity.生菜来源的分泌型 IgA 特异性中和志贺毒素 1 的活性。
Planta. 2019 Oct;250(4):1255-1264. doi: 10.1007/s00425-019-03215-1. Epub 2019 Jun 20.
3
Plant-Produced Chimeric VH-sIgA Against Enterohemorrhagic Intimin Shows Cross-Serotype Inhibition of Bacterial Adhesion to Epithelial Cells.
植物产生的针对肠出血性大肠杆菌紧密素的嵌合VH-sIgA显示出对细菌黏附上皮细胞的跨血清型抑制作用。
Front Plant Sci. 2019 Mar 12;10:270. doi: 10.3389/fpls.2019.00270. eCollection 2019.
4
Transformation strategies for stable expression of complex hetero-multimeric proteins like secretory immunoglobulin A in plants.用于在植物中稳定表达复杂异源多聚体蛋白（如分泌型免疫球蛋白 A）的转化策略。
Plant Biotechnol J. 2019 Sep;17(9):1760-1769. doi: 10.1111/pbi.13098. Epub 2019 Mar 5.
5
Plant-derived secretory component forms secretory IgA with shiga toxin 1-specific dimeric IgA produced by mouse cells and whole plants.植物来源的分泌成分与小鼠细胞和整株植物产生的志贺毒素 1 特异性二聚体 IgA 形成分泌型 IgA。
Plant Cell Rep. 2019 Feb;38(2):161-172. doi: 10.1007/s00299-018-2358-6. Epub 2018 Nov 30.
6
Identification and Characterization of Human Monoclonal Antibodies for Immunoprophylaxis against Enterotoxigenic Escherichia coli Infection.鉴定和表征人源单克隆抗体用于肠毒素性大肠杆菌感染的免疫预防。
Infect Immun. 2018 Jul 23;86(8). doi: 10.1128/IAI.00355-18. Print 2018 Aug.
7
Protection of Human Colon Cells from Shiga Toxin by Plant-based Recombinant Secretory IgA.植物源重组分泌型免疫球蛋白 A 对人结肠细胞免受志贺毒素的保护作用。
Sci Rep. 2017 Apr 3;7:45843. doi: 10.1038/srep45843.
8
Analyzing pepsin degradation assay conditions used for allergenicity assessments to ensure that pepsin susceptible and pepsin resistant dietary proteins are distinguishable.分析用于致敏性评估的胃蛋白酶降解试验条件，以确保对胃蛋白酶敏感和耐受的膳食蛋白质能够区分开来。
PLoS One. 2017 Feb 16;12(2):e0171926. doi: 10.1371/journal.pone.0171926. eCollection 2017.
9
Transient Glyco-Engineering to Produce Recombinant IgA1 with Defined N- and O-Glycans in Plants.通过瞬时糖基工程在植物中生产具有特定N-和O-聚糖的重组IgA1 。
Front Plant Sci. 2016 Jan 29;7:18. doi: 10.3389/fpls.2016.00018. eCollection 2016.
10
Transient Expression of Secretory IgA In Planta is Optimal Using a Multi-Gene Vector and may be Further Enhanced by Improving Joining Chain Incorporation.利用多基因载体在植物中瞬时表达分泌型IgA效果最佳，且通过改善连接链整合可进一步增强表达。
Front Plant Sci. 2016 Jan 11;6:1200. doi: 10.3389/fpls.2015.01200. eCollection 2015.