学术机构中的药物发现早期阶段和制药公司参与推进有前途的先导化合物。
Early Stages of Drug Discovery in an Academic Institution and Involvement of Pharma for Advancing Promising Leads.
出版信息
ACS Infect Dis. 2021 Jul 9;7(7):1874-1876. doi: 10.1021/acsinfecdis.1c00091. Epub 2021 Apr 19.
Abstract
In this Viewpoint, we provide a brief description of two efforts to develop drugs to treat diseases caused by tropical parasites (Malaria, human African trypanosomiasis and Chagas disease). These efforts are largely based in a University setting but draw heavily on Pharma for a complete progression from drug hit discovery to advancement toward clinical trials. The first case is the development of protein farnesyltransferase inhibitors, and the second case is a series of benzthiazoles, the target of which is being investigated.
摘要
在本观点中，我们简要描述了两项开发药物治疗热带寄生虫病（疟疾、非洲人类锥虫病和恰加斯病）的努力。这些努力主要基于大学环境，但在药物发现到临床试验推进的整个过程中严重依赖制药公司。第一个例子是法呢基转移酶抑制剂的开发，第二个例子是一系列苯并噻唑，正在研究其目标。
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