Yin Jia, Zhang Bowei, Yu Zhenting, Hu Yaozhong, Lv Huan, Ji Xuemeng, Wang Jin, Peng Bo, Wang Shuo
Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.
J Agric Food Chem. 2021 Apr 28;69(16):4732-4744. doi: 10.1021/acs.jafc.1c00706. Epub 2021 Apr 19.
Dietary tryptophan affects intestinal homeostasis and neurogenesis, whereas the underlying mechanism and the reciprocal interaction between tryptophan and gut microbiota in aging are unclear. This investigation was performed to determine the effect and mechanism of tryptophan on intestinal- and neuro- health in aging. In present study, the 0.4% tryptophan diet significantly ameliorated the oxidative stress and inflammation in the aging mice, potentially through the regulation of 5'-adenosine monophosphate (AMP)-activated protein kinase (AMPK) and nuclear factor κB (NF-κB) pathways. The 0.4% tryptophan diet increased the levels of indoles in colon contents, which indicated the potential contribution of tryptophan metabolites. Microbiome analysis revealed that the 0.4% tryptophan diet raised the relative abundance of in aging. The ameliorated effect of 0.4% tryptophan on neurodegeneration and neuroinflammation was summarized to potentially rely on the brain-derived neurotrophic factor- (BDNF) and NF-κB-related pathways. These findings provide the research evidence for the beneficial effect of tryptophan on aging.
膳食色氨酸会影响肠道稳态和神经发生，然而色氨酸与肠道微生物群在衰老过程中的潜在机制及相互作用尚不清楚。本研究旨在确定色氨酸对衰老过程中肠道和神经健康的影响及机制。在本研究中，0.4%色氨酸饮食显著改善了衰老小鼠的氧化应激和炎症，这可能是通过调节5'-单磷酸腺苷（AMP）激活的蛋白激酶（AMPK）和核因子κB（NF-κB）信号通路实现的。0.4%色氨酸饮食增加了结肠内容物中吲哚的水平，这表明色氨酸代谢产物具有潜在作用。微生物组分析显示，0.4%色氨酸饮食提高了衰老小鼠中[此处原文缺失相关微生物名称]的相对丰度。0.4%色氨酸对神经退行性变和神经炎症的改善作用总结为可能依赖于脑源性神经营养因子（BDNF）和NF-κB相关信号通路。这些发现为色氨酸对衰老的有益作用提供了研究证据。
