Bel-Hadj-Ali Z, Dufour V, Najean Y
Service de Médecine Nucléaire, Hôpital Saint-Louis, Paris, France.
Nouv Rev Fr Hematol (1978). 1988;30(1-2):65-8.
In the last 2 years, 46 cases of HIV-induced pure thrombocytopenias have been studied, using either autologous 111 In-labeled platelets and/or homologous 51Cr-labeled platelets. The most interesting data seem to be: more than 50% of the cases were observed in young, drug addicts, a population statistically different from the general epidemiological survey of AIDS; in most the cases, thrombocytopenia was an isolated symptom with no other symptoms due to the HIV infection, or any other hematological abnormality; cortico steroids and immunoglobulins were either inefficient or only temporarily useful. In contrast splenectomy was efficient, at short or middle-term, in 12 cases of the present series; this last fact correlated with the splenic sequestration observed in almost all the cases; the platelet life-span was short in all these patients, except those with AIDS disease and pan myelopathy.
在过去两年中，我们对46例由人类免疫缺陷病毒（HIV）引起的单纯性血小板减少症进行了研究，采用了自体111铟标记血小板和/或同源51铬标记血小板。最有趣的数据似乎是：超过50%的病例见于年轻的吸毒者，这一人群在统计学上与艾滋病的一般流行病学调查结果不同；在大多数病例中，血小板减少是一种孤立的症状，没有因HIV感染或任何其他血液学异常引起的其他症状；皮质类固醇和免疫球蛋白要么无效，要么仅暂时有效。相比之下，在本系列的12例病例中，脾切除术在短期或中期是有效的；这一最后事实与几乎所有病例中观察到的脾脏扣押有关；除患有艾滋病和全髓病的患者外，所有这些患者的血小板寿命均较短。
