Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
DNA Cell Biol. 2021 Jun;40(6):713-719. doi: 10.1089/dna.2020.6453. Epub 2021 Apr 19.
Coronavirus disease 2019 (COVID-19) is the worst public health crisis of the century. Although we have made tremendous progress in understanding the pathogenesis of this disease, a lot more remains to be learned. Mitochondria appear to be important in COVID-19 pathogenesis because of its role in innate antiviral immunity, as well as inflammation. This article examines pathogenesis of COVID-19 from a mitochondrial perspective and tries to answer some perplexing questions such as why the prognosis is so poor in those with obesity, metabolic syndrome, or type 2 diabetes. Although effective vaccines and antiviral drugs will be the ultimate solution to this crisis, a better understanding of disease mechanisms will open novel avenues for treatment and prevention.
2019 年冠状病毒病（COVID-19）是本世纪最严重的公共卫生危机。尽管我们在理解这种疾病的发病机制方面取得了巨大进展，但仍有许多需要了解。线粒体在 COVID-19 的发病机制中似乎很重要，因为它在先天抗病毒免疫以及炎症中发挥作用。本文从线粒体的角度探讨 COVID-19 的发病机制，并试图回答一些令人困惑的问题，例如为什么肥胖、代谢综合征或 2 型糖尿病患者的预后如此之差。虽然有效的疫苗和抗病毒药物将是解决这场危机的最终办法，但更好地了解疾病机制将为治疗和预防开辟新的途径。
