1Departamento de Física, Instituto de Biociências Letras e Ciências Exatas, Centro Multiusuário de Inovação Biomolecular, Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP), São José do Rio Preto, Brazil.
2Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Laboratório de Parasitologia, Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP), Araraquara, Brazil.
Am J Trop Med Hyg. 2021 Apr 19;104(6):1973-1977. doi: 10.4269/ajtmh.20-1047.
Chagas disease is an illness caused by the protozoan Trypanosoma cruzi that is distributed in 21 countries of Latin America. The main way of transmission of T. cruzi is through the feces of triatomines infected with the parasite. With technological advances came new technologies called omics. In the pre-genomic era, the omics science was based on cytogenomic studies of triatomines. With the Rhodnius prolixus genome sequencing project, new omics tools were applied to understand the organism at a systemic level and not just from a genomic point of view. Thus, the present review aims to put together the cytogenomic and genomic information available in the literature for Chagas disease vectors. Here, we review all studies related to cytogenomics and genomics of Chagas disease vectors, contributing to the direction of further research with these insect vectors, because it was evident that most studies focus on cytogenomic knowledge of the species. Given the importance of genomic studies, which contributed to the knowledge of taxonomy, systematics, as well as the vector's biology, the need to apply these techniques in other genera and species of Triatominae subfamily is emphasized.
恰加斯病是一种由原生动物克氏锥虫引起的疾病，分布在拉丁美洲的 21 个国家。克氏锥虫的主要传播途径是通过感染寄生虫的三锥虫的粪便。随着技术的进步，出现了一些新的技术，称为组学。在基因组时代之前，组学科学基于三锥虫的细胞基因组研究。随着 Rhodnius prolixus 基因组测序项目的开展，新的组学工具被应用于从系统水平而不仅仅是从基因组角度来理解生物体。因此，本综述旨在汇集恰加斯病传播媒介的细胞基因组和基因组信息。在这里，我们回顾了与恰加斯病传播媒介的细胞遗传学和基因组学相关的所有研究，为进一步研究这些昆虫媒介提供了方向，因为很明显，大多数研究都集中在对这些物种的细胞遗传学知识上。鉴于基因组研究对分类学、系统学以及媒介生物学知识的重要性，强调需要将这些技术应用于其他三锥虫亚科的属和种。
