1Department of Infectious Diseases, University of São Paulo Medical School, São Paulo, Brazil.
2Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil.
Am J Trop Med Hyg. 2021 Apr 19;104(6):1970-1972. doi: 10.4269/ajtmh.20-1000.
Based on a previous study and by incorporating new knowledge, the goal of our study was to understand more fully the pathogenesis of hemorrhagic pneumonia of severe human leptospirosis, highlighting the onset of capillary lesions by Leptospira itself and/or its antigenic/toxic products acting on the endothelium and binding to cadherins. Both events lead to loss of endothelial integrity, alter permeability, cause rupture, and open intercellular junctions, contributing to the hemorrhagic phenomena associated with severe leptospirosis.
基于先前的研究，并结合新的知识，我们的研究旨在更全面地了解人类严重钩端螺旋体病出血性肺炎的发病机制，强调由钩端螺旋体本身及其抗原/毒性产物作用于内皮细胞并与钙黏蛋白结合引起的毛细血管损伤的发生。这两个事件都会导致内皮完整性丧失、通透性改变、破裂和细胞间连接开放，从而导致与严重钩端螺旋体病相关的出血现象。
