School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu, India.
Centre for Research and Postgraduate Studies in Botany, Ayya Nadar Janaki Ammal College (Autonomous), Sivakasi, Tamil Nadu, India.
Z Naturforsch C J Biosci. 2021 Apr 20;76(9-10):383-391. doi: 10.1515/znc-2020-0153. Print 2021 Sep 27.
and are known for their folk medicinal usage in treating gastrointestinal ailments. The spasmolytic activity of essential oils was studied using isolated rat ileum. The results indicate that , despite having a lower content of eugenol (60%), shows a spasmolytic potential of 68.01 ± 2.63% (EC = 110.12 ± 13.58 μg/mL) while with rich eugenol (80%) shows lesser spasmolytic potential (38.96 ± 0.63%) and fails to attain an EC value. Upon comparison with standard eugenol's percentage of spasmolytic (35.68 ± 2.57%), it is evident that the action of these essential oils does not solely rely on the major component but the synergistic role in association with other components of the mixture influences the pharmacological action of the essential oils. docking of phytochemicals of leaf essential oils with M (MAChR) and M muscarinic (MAChR) and nicotinic acetylcholine receptor (nAChR) was carried out to determine the type of receptors through which the essential oils had spasmolytic potential. The binding affinity for eugenol with nAChR shows a better docking score than MAChR and MAChR.
和 因其在治疗胃肠道疾病方面的民间药用价值而闻名。使用分离的大鼠回肠研究了精油的解痉活性。结果表明，尽管 中的丁香酚含量较低（60%），但其表现出 68.01±2.63%（EC=110.12±13.58μg/mL）的解痉潜力，而含有丰富丁香酚（80%）的 则显示出较小的解痉潜力（38.96±0.63%），并且无法达到 EC 值。与标准丁香酚的解痉百分比（35.68±2.57%）相比，很明显，这些精油的作用不仅取决于主要成分，而且与混合物中其他成分的协同作用会影响精油的药理作用。对叶片精油的植物化学成分与 M（MAChR）和 M 毒蕈碱（MAChR）和烟碱型乙酰胆碱受体（nAChR）进行对接，以确定精油具有解痉潜力的受体类型。与 MAChR 和 MAChR 相比，丁香酚与 nAChR 的结合亲和力显示出更好的对接评分。
