Department of Vascular Surgery, Royal Free London NHS Foundation Trust, London, United Kingdom; Division of Surgery & Interventional Science, Department of Surgical Biotechnology, Faculty of Medical Sciences, University College London, London, United Kingdom.
Department of Vascular Surgery, Royal Free London NHS Foundation Trust, London, United Kingdom.
J Vasc Surg Venous Lymphat Disord. 2022 Jan;10(1):159-169. doi: 10.1016/j.jvsv.2021.03.019. Epub 2021 Apr 17.
Patients with vascular malformations suffer from chronic debilitating symptoms that have been shown to contribute negatively to their quality of life (QoL) and mental health. Despite this, the current literature evaluating the QoL and mental health of patients with vascular malformations remains scarce. Our aim was to evaluate the QoL and mental health of patients with vascular malformations.
We prospectively analyzed the validated health-related QoL (HRQoL) questionnaires: the RAND Health Care 36-Item Short Form Survey (SF-36), Hospital Anxiety and Depression Scale (HADS), and visual analogue score for pain reported by 253 patients with vascular malformations in a specialist center of vascular anomalies in the UK over 2 years.
Patients with vascular malformations reported significantly poorer SF-36 scores in all domains compared with the UK general population. Patients with low-flow vascular malformations and arteriovenous malformations reported little variations in SF-36, HADS, and visual analogue score for pain scores. No significant association was found between age and any of the health-related QoL scores, other than the physical functioning in SF-36. Female patients reported significantly lower physical and social functioning of SF-36 and worse HADS-Depression than their male counterparts. Patients with syndromic vascular malformations reported significantly lower SF-36 scores in role-physical, role-emotional and bodily pain than nonsyndromic vascular malformations.
This study concluded that patients with vascular malformations reported worse QoL than the UK general population. Therefore, the assessment and management of QoL and mental health should be incorporated into the overall treatment strategies of patients with vascular malformations.
患有血管畸形的患者会遭受慢性衰弱症状的折磨，这些症状已被证明会对他们的生活质量（QoL）和心理健康产生负面影响。尽管如此，目前评估血管畸形患者 QoL 和心理健康的文献仍然很少。我们的目的是评估血管畸形患者的 QoL 和心理健康。
我们前瞻性地分析了经过验证的健康相关 QoL（HRQoL）问卷：RAND 健康护理 36 项简明健康调查问卷（SF-36）、医院焦虑和抑郁量表（HADS）以及英国血管异常专科中心的 253 例血管畸形患者报告的疼痛视觉模拟评分，共持续 2 年。
与英国普通人群相比，患有血管畸形的患者在所有领域的 SF-36 评分均显著较差。低流量血管畸形和动静脉畸形患者的 SF-36、HADS 和疼痛视觉模拟评分变化不大。除 SF-36 的身体机能外，年龄与任何健康相关 QoL 评分之间均无显著关联。女性患者的 SF-36 身体和社会功能以及 HADS 抑郁评分明显低于男性患者。患有综合征性血管畸形的患者的 SF-36 角色身体功能、角色情感和躯体疼痛评分明显低于非综合征性血管畸形患者。
本研究得出的结论是，血管畸形患者报告的 QoL 比英国普通人群差。因此，应将 QoL 和心理健康的评估和管理纳入血管畸形患者的整体治疗策略中。
