Wang Xiang, Yan Xin, Wang Bin-Cheng, Xue Wei, Zhou Chang-Ren, Zhang Yi, Liu Zong-Hua
Guangdong Provincial Engineering and Technological Research Center for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, China.
Biosens Bioelectron. 2021 Jul 15;184:113230. doi: 10.1016/j.bios.2021.113230. Epub 2021 Apr 7.
Blood lead poisoning is a universal and severe health problem that greatly threatens human health in various industries. Elimination of blood lead relying on chelating agents and combination with hemoperfusion adsorbents has achieved considerable progress, but it is still suffering from the compromised selectivity of adsorbents as well as in absence of real time monitoring during treatment. Herein, we proposed a selective blood lead adsorbent integrated with real-time visualized/electrochemical bi-modal monitoring based on TMPyP-bound guanosine-borate (GB) supramolecular hydrogel as potential smart hemoperfusion device. The GB hydrogel possessed stability in physiological environment, self-healing ability resistant to fluid shear, blood compatibility, selective adsorption of lead ions superior to conventional adsorbents, anti-fouling performance to blood components and renewability. Benefiting from binding with TMPyP and the intrinsic conductivity, GB hydrogel was endowed with the ability to qualitatively diagnose the presence of blood lead via simple color change and quantitatively reflect the amount of adsorbed lead from blood accurately through electrochemical technique. This work puts forward an integrated treatment/monitoring hemoperfusion device with high selectivity, simple fabrication and low-cost, providing a paradigm for next generation design of intelligent, monitorable theranostic hemopurification system, which is also an extensible platform for the other research fields such as environmental monitoring and remediation.
血铅中毒是一个普遍且严重的健康问题，在各个行业中都对人类健康构成了巨大威胁。依靠螯合剂和血液灌流吸附剂联合来消除血铅已取得了显著进展，但仍存在吸附剂选择性不足以及治疗过程中缺乏实时监测等问题。在此，我们基于四甲基吡啶卟啉结合的鸟苷硼酸（GB）超分子水凝胶，提出了一种集成实时可视化/电化学双模态监测的选择性血铅吸附剂，作为潜在的智能血液灌流装置。GB水凝胶在生理环境中具有稳定性、抗流体剪切的自愈能力、血液相容性、对铅离子的选择性吸附优于传统吸附剂、对血液成分的抗污性能以及可更新性。得益于与四甲基吡啶卟啉的结合和其固有导电性，GB水凝胶具备通过简单的颜色变化定性诊断血铅存在的能力，并能通过电化学技术准确地定量反映从血液中吸附的铅含量。这项工作提出了一种具有高选择性、制备简单且成本低廉的集成治疗/监测血液灌流装置，为下一代智能、可监测的治疗诊断血液净化系统的设计提供了范例，同时也是环境监测与修复等其他研究领域的一个可扩展平台。
