Department of Obstetrics & Gynecology, Medical University of Graz, Austria.
Department of Obstetrics & Gynecology, Medical University of Graz, Austria.
Eur J Obstet Gynecol Reprod Biol. 2021 Jun;261:34-40. doi: 10.1016/j.ejogrb.2021.04.011. Epub 2021 Apr 14.
We aim to describe the history of iodine testing of the cervix and identify areas where further work is required.
We conducted a search of PubMed and Google Scholar. Full article texts were reviewed. Reference lists were screened for additional articles and books. 37 basic articles in journals including ones written in German and three basic articles in books were identified.
Glycogen staining of the ectocervical squamous epithelium with iodine goes back to Paul Ehrlich (1854-1915). Walter Schiller (1887-1960) examined nearly 200 different dyes and found that vital staining of the cervical squamous epithelium was best achieved with Lugol's iodine solution, which was indicated by Jean Guillaume Lugol (1786-1851) for disinfection of the vagina. In 1928 W. Lahm observed that the glycogen content of a squamous epithelium cell decreases as anaplasia increases. From the outset, H. Hinselmann included the iodine test in the minimum requirements for colposcopy. In 1946 H. J. Wespi first mentioned the finding of an "uncharacteristic iodine negative area." The first international colposcopic terminology from Graz in 1975 lists the "iodine light area" among the different colposcopy findings. The IFCPC nomenclatures from Rome 1990, Barcelona 2002, and Rio de Janeiro 2011 have evaluated the iodine test and classified their findings differently. A breakthrough to effective cervical cancer screening in resource-limited settings in Africa, India, and Latin America was achieved with R. Sankaranarayanan's publication on naked-eye visual inspection of the cervix after application of Lugol's iodine.
This paper is a step toward a better understanding of what we think and do today with iodine testing and what problems and upcoming tasks will arise in future.
我们旨在描述宫颈碘测试的历史，并确定需要进一步研究的领域。
我们在 PubMed 和 Google Scholar 上进行了搜索。查看全文文本。筛选参考文献列表以获取其他文章和书籍。共确定了 37 篇期刊基础文章，包括德文文章，以及三本书籍中的三篇基础文章。
用碘对宫颈外鳞状上皮进行糖原染色可追溯到保罗·埃尔利希（1854-1915 年）。沃尔特·席勒（1887-1960 年）检查了近 200 种不同的染料，发现卢戈氏碘溶液最能实现宫颈鳞状上皮的有生机染色，这是让·纪尧姆·卢戈（1786-1851 年）为阴道消毒而指出的。1928 年，W. Lahm 观察到随着异形增生的增加，鳞状上皮细胞的糖原含量减少。从一开始，H. Hinselmann 就将碘试验纳入阴道镜检查的最低要求。1946 年，H. J. Wespi 首次提到发现“无特征性碘阴性区域”。1975 年来自格拉茨的第一个国际阴道镜术语列出了不同阴道镜检查结果中的“碘光区”。1990 年罗马、2002 年巴塞罗那和 2011 年里约热内卢的 IFCPC 命名法对碘试验进行了评估，并对其发现进行了不同的分类。R. Sankaranarayanan 发表的关于应用卢戈氏碘后肉眼观察宫颈的裸眼视觉检查，为在非洲、印度和拉丁美洲资源有限的环境中实现有效的宫颈癌筛查取得了突破。
本文旨在帮助我们更好地理解今天我们对碘试验的想法和做法，以及未来可能出现的问题和即将到来的任务。
