Applicability of GLI 2012 spirometry equation among preschool aged Jordanian.

OBJECTIVES

The Validation of Global Lung Initiative (GLI 2012) equations is required prior to their application in clinical practice in different regions. This study validated the GLI 2012 equations in Middle Eastern preschool aged children, which was not previously conducted.

STUDY DESIGN

Spirometry measures were collected from 765 (54% males) healthy 3 to 5-year-old Jordanian children. z scores, percent predicted values, and frequency of measures below lower limit than normal (LLN) were calculated using GLI 2012 equations for Caucasians and Other or Mixed.

RESULTS

The mean of z-scores produced by GLI 2012 equation for Caucasians in FEV, FEV, FVC, FEV/FVC% and FEF25-75 in boys were 0.03, 0.02, -0.13, 0.26 and -0.08 respectively, while in girls it was -0.03, 0.01, 0.02, -0.01 and -0.04 respectively, and the mean of z-scores produced by GLI-2012 Other or Mixed equations in FEV, FVC, FEV/FVC% and FEF25-75 in boys were 0.56, 0.51, 0.09 and 0.12 respectively, and in girls it was 0.56, 0.67, -0.22 and 0.18 respectively. The frequency of measures below LLN as produced by Caucasians equation were not significantly different from the expected 5% in any of the spirometry parameters.

CONCLUSION

The GLI 2012 for Caucasians is a reasonable fit for Jordanian preschool aged children.