Almeida Lins Wylisson Marcelo, Tura Bernardo Rangel, Kasal Daniel Arthur
Research Division, National Institute of Cardiology, Ministry of Health, Rio de Janeiro, Brazil.
Research Division, National Institute of Cardiology, Ministry of Health, Rio de Janeiro, Brazil; State University of Rio de Janeiro, Internal Medicine Department, Rio de Janeiro, Brazil.
Value Health Reg Issues. 2021 Sep;25:112-117. doi: 10.1016/j.vhri.2021.01.005. Epub 2021 Apr 15.
Chagas disease (CD) is a chronic disease to millions worldwide, and many patients develop heart disease. In addition, they are part of an aging population. These characteristics can be associated with a reduction in physical performance and health-related quality of life (HRQoL). This study evaluated HRQoL, and the relationship between physical performance and HRQoL in patients with chronic CD.
We used the 3-level version of EuroQol 5-dimensional questionnaire (EQ-5D-3L), with the visual analog scale (VAS). Physical performance was measured with 30-s chair-stand test (30sCST) and timed up and go test (TUGT).
Sixty-three patients were evaluated. The majority were women (68.2%) aged 67.7 ± 9.7 years. Overall EQ-5D-3L utility index was 0.65 ± 0.28, and VAS score was 68.4 ± 25.1. Most patients with intermediate and high performance in 30sCST referred no problems in the domains "mobility," "usual activities," and "pain/feeling ill" (P < .001, P = .01, and P = .025, respectively). In a similar way, most patients with intermediate and high performance in TUGT referred no problems in "mobility" (P < .0001) and "usual activities" (P = .001). Higher performance in both tests was associated with higher overall EQ-5D-3L utility and VAS scores. HRQoL measured by EQ-5D-3L was associated with physical status in a cohort of patients with chronic CD. The results underscore the contribution of physical performance, measured by 2 inexpensive and safe physical tests, to HRQoL in these patients.
Strategies aiming the improvement of HRQoL in patients with CD may focus on mobility skills and force. Future studies evaluating interventions in physical performance should be a priority in these patients.
恰加斯病（CD）是一种影响全球数百万人的慢性疾病，许多患者会发展为心脏病。此外，他们属于老龄人口。这些特征可能与身体机能下降以及健康相关生活质量（HRQoL）降低有关。本研究评估了慢性CD患者的HRQoL以及身体机能与HRQoL之间的关系。
我们使用了带有视觉模拟量表（VAS）的3级版本欧洲五维度健康量表（EQ-5D-3L）。通过30秒椅子站立试验（30sCST）和计时起立行走试验（TUGT）来测量身体机能。
共评估了63名患者。大多数为女性（68.2%），年龄为67.7±9.7岁。总体EQ-5D-3L效用指数为0.65±0.28，VAS评分为68.4±25.1。在30sCST中表现为中等及高水平的大多数患者在“行动能力”“日常活动”和“疼痛/不适”领域均未提及问题（分别为P<.001、P=.01和P=.025）。同样，在TUGT中表现为中等及高水平的大多数患者在“行动能力”（P<.0001）和“日常活动”（P=.001）方面未提及问题两个试验中较高的表现水平与更高的总体EQ-5D-3L效用和VAS评分相关。在一组慢性CD患者中，通过EQ-5D-3L测量的HRQoL与身体状况相关。结果强调了通过两项廉价且安全的身体测试所测量的身体机能对这些患者HRQoL的贡献。
旨在改善CD患者HRQoL的策略可侧重于行动能力技能和力量。未来评估身体机能干预措施的研究应成为这些患者的优先事项。
