Research Division, National Institute of Cardiology, Ministry of Health, Rio de Janeiro, Brazil.
Research Division, National Institute of Cardiology, Ministry of Health, Rio de Janeiro, Brazil; State University of Rio de Janeiro, Internal Medicine Department, Rio de Janeiro, Brazil.
Value Health Reg Issues. 2021 Dec;26:191-196. doi: 10.1016/j.vhri.2021.09.002. Epub 2021 Oct 30.
Chagas disease (CD) is a chronic disease to millions worldwide, and many patients develop heart disease. In addition, they are part of an aging population. These characteristics can be associated with a reduction in physical performance and health-related quality of life (HRQoL). This study evaluated HRQoL, and the relationship between physical performance and HRQoL in patients with chronic CD.
We used the 3-level version of EuroQol 5-dimensional questionnaire (EQ-5D-3L), with the visual analog scale (VAS). Physical performance was measured with 30-s chair-stand test (30sCST) and timed up and go test (TUGT).
Sixty-three patients were evaluated. The majority were women (68.2%) aged 67.7 ± 9.7 years. Overall EQ-5D-3L utility index was 0.65 ± 0.28, and VAS score was 68.4 ± 25.1. Most patients with intermediate and high performance in 30sCST referred no problems in the domains "mobility," "usual activities," and "pain/feeling ill" (P < .001, P = .01, and P = .025, respectively). In a similar way, most patients with intermediate and high performance in TUGT referred no problems in "mobility" (P < .0001) and "usual activities" (P = .001). Higher performance in both tests was associated with higher overall EQ-5D-3L utility and VAS scores. HRQoL measured by EQ-5D-3L was associated with physical status in a cohort of patients with chronic CD. The results underscore the contribution of physical performance, measured by 2 inexpensive and safe physical tests, to HRQoL in these patients.
Strategies aiming the improvement of HRQoL in patients with CD may focus on mobility skills and force. Future studies evaluating interventions in physical performance should be a priority in these patients.
恰加斯病（CD）是一种影响全球数百万人的慢性疾病，许多患者会发展为心脏病。此外，他们属于老龄化人口。这些特征可能与身体机能下降和健康相关生活质量（HRQoL）降低有关。本研究评估了慢性 CD 患者的 HRQoL 以及身体机能与 HRQoL 之间的关系。
我们使用了欧洲五维健康量表 3 级版本（EQ-5D-3L），并结合视觉模拟量表（VAS）。身体机能通过 30 秒椅子站立测试（30sCST）和计时起立行走测试（TUGT）进行测量。
共评估了 63 名患者，大多数为女性（68.2%），年龄为 67.7 ± 9.7 岁。总体 EQ-5D-3L 效用指数为 0.65 ± 0.28，VAS 评分为 68.4 ± 25.1。在 30sCST 中表现为中等到高等的大多数患者在“移动性”、“日常活动”和“疼痛/不适”方面没有问题（P<.001，P=0.01 和 P=0.025）。同样，在 TUGT 中表现为中等到高等的大多数患者在“移动性”（P<.0001）和“日常活动”（P=0.001）方面没有问题。这两种测试中表现越好，总体 EQ-5D-3L 效用和 VAS 评分越高。通过 EQ-5D-3L 测量的 HRQoL 与慢性 CD 患者的身体状况相关。这些结果强调了通过 2 种简单且安全的体能测试来提高 CD 患者 HRQoL 的重要性。未来评估身体机能干预措施的研究应优先考虑这些患者。
