Akinyanju J, Smith R J
Department of Biological Sciences, University of Lancaster, Lancaster LAI 4YQ, UK.
New Phytol. 1987 Jan;105(1):117-122. doi: 10.1111/j.1469-8137.1987.tb00115.x.
Two highly phosphorylated guanosine derivatives accumulate in alkaline cultures of Anabaena cylindrica during the early stationary phase and in anaerobic, nitrogen-deprived cultures. The accumulation of these nucleotides is accompanied by the suppression of the normal accumulation of ppGpp and ppGppp, nucleotides which are effectors of the stringent response in bacteria. The accumulation of the two sets of nucleotides appears to be mutually exclusive. The accumulation of the guanosine derivatives during growth inhibition and their replacement of ppGpp and pppGpp suggests that the newly discovered guanine compounds may also fulfil a regulatory role.
在柱状鱼腥藻的碱性培养物中，两种高度磷酸化的鸟苷衍生物在稳定期早期以及厌氧、缺氮培养物中积累。这些核苷酸的积累伴随着细菌中严谨反应的效应物ppGpp和ppGppp正常积累的抑制。两组核苷酸的积累似乎是相互排斥的。鸟苷衍生物在生长抑制期间的积累以及它们对ppGpp和pppGpp的替代表明，新发现的鸟嘌呤化合物可能也发挥着调节作用。
