Ritter J M, Frazer C E, Powell J T, Taylor G W
Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, U.K.
Prostaglandins Leukot Essent Fatty Acids. 1988 Apr;32(1):29-32. doi: 10.1016/0952-3278(88)90090-7.
Sliced portions of the walls of human aortic aneurysms were incubated with extracts of human plasma and serum to determine the profile of prostanoid production. 6-Oxo-prostaglandin (PG) F1 alpha, PGE2, PGF2 alpha, and thromboxane (TX) B2 were measured by gas chromatography/electron capture mass spectrometry. 6-Oxo-PGF1 alpha, the stable hydrolysis product of PGI2, was the major cyclooxygenase product but substantial amounts of TXB2 (the hydrolysis product of TXA2), with smaller amounts of PGE2 and PGF2 alpha were also synthesised. These prostanoids could contribute to the response of the vascular wall to injury, thereby influencing the disease process. Serum extracts stimulated PGI2 and TXA2 synthesis, probably as a result of their Ca2+ content.
将人类主动脉瘤壁的切片部分与人类血浆和血清提取物一起孵育，以确定前列腺素的产生情况。通过气相色谱/电子捕获质谱法测量6-氧代前列腺素（PG）F1α、PGE2、PGF2α和血栓素（TX）B2。6-氧代-PGF1α是前列环素（PGI2）的稳定水解产物，是主要的环氧化酶产物，但也合成了大量的TXB2（血栓素A2（TXA2）的水解产物），以及少量的PGE2和PGF2α。这些前列腺素可能有助于血管壁对损伤的反应，从而影响疾病进程。血清提取物刺激PGI2和TXA2的合成，可能是由于其钙含量所致。
