Kidney Research Institute, Division of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China.
Curr Med Chem. 2021;28(36):7413-7426. doi: 10.2174/0929867328666210419132807.
Considerable evidence has proved that disturbed cholesterol metabolism played a crucial role in diabetic kidney disease. Besides, massive cholesterol depositions were found in intrinsic renal cells of diabetic kidney disease patients and animal models, causing cytotoxicity and affecting renal function. Statins could alleviate cholesterol depositions, podocyte injury, and microalbuminuria of diabetic kidney disease. In this review, we summarized the process of disturbed cholesterol metabolism and discussed how it induced kidney dysfunction in diabetic kidney disease.
大量证据表明，胆固醇代谢紊乱在糖尿病肾病中起着关键作用。此外，在糖尿病肾病患者和动物模型的固有肾细胞中发现了大量胆固醇沉积，导致细胞毒性并影响肾功能。他汀类药物可减轻胆固醇沉积、足细胞损伤和糖尿病肾病的微量白蛋白尿。在这篇综述中，我们总结了胆固醇代谢紊乱的过程，并讨论了它如何导致糖尿病肾病中的肾功能障碍。
