Department of Infectious Diseases, Tuzla University Clinical Center, Ibre Pasica bb, 7500, Tuzla, Bosnia and Herzegovina.
Department for Family Medicine, King Fahad Medical City, As Sulimaniyah, Riyadh, 12231, Saudi Arabia.
BMC Infect Dis. 2021 Apr 19;21(1):367. doi: 10.1186/s12879-021-06034-6.
Since the outbreak of COVID-19 pandemic, clinical data from various parts of the world have been reported. Up till now, there has been no clinical data with regards to COVID-19 from Bosnia and Herzegovina (B&H). The aim was to report on the first cohort of patients from B&H and to analyze factors that influence COVID-19 patient's length of hospitalization (LOH).
This retrospective cohort study was conducted at Tuzla University Clinical Center (UKC), B&H. It involved 25 COVID-19 positive patients that needed hospitalisation between March 28th and April 27th 2020. The LOH was measured from the time of admission to discharge. Factors analyzed induced age, BMI, presence of known comorbidities, serum creatinine and O saturation upon admission.
The mean age was 52.92 ± 19.15 years and BMI 28.80 ± 4.22. LOH for patients with BMI < 25 was 9 ± SE2.646 days (CI 95% 3.814-14.816) vs 14.182 ± SE .937 (CI 95% 12.346-16.018 p < 0.05; HR 5.148 CI95% 1.217 to 21.772 p = 0.026) for ≥25 BMI. The mean LOH of patients with normal levels of O ≥ 95% was 11.667 ± SE1.202 (CI95% 8.261 to 13.739; p = 0.046), while LOH for patients with < 95% was 14.625 ± SE 1.231 CI95% 12.184 to 16.757 p = 0.042; HR 3.732 CI95%1.137-12.251 p = 0.03). Patients without known comorbidities had a mean LOH of 11.700 ± SE1.075 (CI 95% 9.592-13.808), while those with comorbidities had a mean of 14.8 ± 1.303 (CI 95% 12.247-17.353; p = 0.029) with HR2.552.
LOH varied among COVID-19 patients and was prolonged when analyzed for BMI ≥25, comorbidities, elevated creatinine, and O2 saturation < 95%. Furthermore, risk factors for COVID-19 patients in B&H do not deviate from those reported in other countries.
自 COVID-19 大流行爆发以来,来自世界各地的临床数据陆续被报道。截至目前,波黑(B&H)尚无 COVID-19 的临床数据。本研究旨在报告波黑的首批 COVID-19 患者队列,并分析影响 COVID-19 患者住院时间(LOH)的因素。
这是一项在波黑图兹拉大学临床中心(UKC)进行的回顾性队列研究。共纳入 2020 年 3 月 28 日至 4 月 27 日期间需要住院治疗的 25 例 COVID-19 阳性患者。从入院到出院的时间为 LOH 测量时间。分析的因素包括年龄、BMI、是否存在已知合并症、入院时的血清肌酐和 O 饱和度。
患者的平均年龄为 52.92±19.15 岁,BMI 为 28.80±4.22。BMI<25 的患者的 LOH 为 9±SE2.646 天(95%CI 95% 3.814-14.816),而 BMI≥25 的患者的 LOH 为 14.182±SE0.937(95%CI 95% 12.346-16.018,p<0.05;HR 5.148 CI95% 1.217-21.772,p=0.026)。O 饱和度≥95%的患者的平均 LOH 为 11.667±SE1.202(95%CI95% 8.261-13.739;p=0.046),而 O 饱和度<95%的患者的 LOH 为 14.625±SE1.231(95%CI95% 12.184-16.757,p=0.042;HR 3.732 CI95%1.137-12.251,p=0.03)。无已知合并症的患者的平均 LOH 为 11.700±SE1.075(95%CI 95% 9.592-13.808),而有合并症的患者的平均 LOH 为 14.8±1.303(95%CI 95% 12.247-17.353;p=0.029),HR 为 2.552。
COVID-19 患者的 LOH 存在差异,当 BMI≥25、合并症、肌酐升高和 O2 饱和度<95%时,LOH 延长。此外,波黑 COVID-19 患者的危险因素与其他国家报告的危险因素并无差异。