Postdoctoral student, Oral Oncology Center, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil.
Doctoral student, Oral Oncology Center, Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil.
J Prosthet Dent. 2022 Oct;128(4):548-553. doi: 10.1016/j.prosdent.2020.12.032. Epub 2021 Apr 17.
Undifferentiated pleomorphic sarcoma is a high-grade soft-tissue malignant tumor that is rare in the head and neck region. A 74-year-old woman displayed a large nodular lesion in the maxillary alveolar mucosa, which was initially identified as denture-related fibrous hyperplasia. Although her prosthodontist has adjusted the maxillary complete denture to relieve pressure on the lesion, it increased in size over time. Computed tomography images of the maxillary sinus showed an extensive destructive lesion. A biopsy was performed, and microscopic examination revealed a poorly differentiated malignancy with numerous spindle cells. Immunohistochemistry reactions were negative for CD45, CD30, CD68, CD34, cytokeratin, S100, desmin, and smooth muscle actin. These findings led to the diagnosis of an undifferentiated pleomorphic sarcoma of the maxillary sinus.
未分化多形性肉瘤是一种高级别的软组织恶性肿瘤，在头颈部较为罕见。一位 74 岁女性的上颌牙槽黏膜出现了一个大的结节状病变，最初被诊断为与义齿相关的纤维组织增生。尽管她的义齿医生已调整了上颌全口义齿以减轻病变处的压力，但随着时间的推移，病变仍逐渐增大。上颌窦的计算机断层扫描图像显示出广泛的破坏性病变。进行了活检，显微镜检查显示出低度分化的恶性肿瘤，其中有许多梭形细胞。免疫组织化学反应 CD45、CD30、CD68、CD34、细胞角蛋白、S100、结蛋白和平滑肌肌动蛋白均为阴性。这些发现导致了上颌窦未分化多形性肉瘤的诊断。
