Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Molecular and Translational Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.
Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Molecular and Translational Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.
Cytokine. 2021 Jul;143:155520. doi: 10.1016/j.cyto.2021.155520. Epub 2021 Apr 16.
Chronic lung diseases including asthma, chronic obstructive pulmonary disease (COPD) and lung fibrosis represent a major burden on healthcare systems with limited effective therapeutic options. Developing effective treatments for these debilitating diseases requires an understanding of how alterations at the molecular level affect lung macroscopic architecture. A common theme among these lung disorders is the presence of an underlying dysregulated immune system which can lead to sustained chronic inflammation. In this respect, several inflammatory cytokines have been implicated in the pathogenesis of lung diseases, thus leading to the notion that cytokines are attractive therapeutic targets for these disorders. In this review, we discuss and highlight the recent breakthroughs that have enhanced our understanding of the role of the interleukin (IL)-6 family of cytokines in lung homeostasis and chronic diseases including asthma, COPD, lung fibrosis and lung cancer.
慢性肺部疾病包括哮喘、慢性阻塞性肺疾病（COPD）和肺纤维化，这些疾病给医疗系统带来了重大负担，而目前有效的治疗选择有限。要为这些使人虚弱的疾病开发有效的治疗方法，就需要了解分子水平的变化如何影响肺部的宏观结构。这些肺部疾病的一个共同主题是存在潜在失调的免疫系统，这可能导致持续的慢性炎症。在这方面，几种炎症细胞因子已被牵涉到肺部疾病的发病机制中，因此细胞因子成为这些疾病有吸引力的治疗靶点。在这篇综述中，我们讨论并强调了最近的突破，这些突破增强了我们对白细胞介素（IL）-6 细胞因子家族在肺部稳态和包括哮喘、COPD、肺纤维化和肺癌在内的慢性疾病中的作用的理解。
