Department of Pharmacy, Barnes-Jewish Hospital, St. Louis, Missouri, USA.
Division of Infectious Disease, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0246020. doi: 10.1128/AAC.02460-20.
This retrospective single-center study of a cohort of adult patients who received voriconazole with a steady-state trough concentration measured during therapy evaluated the rate of therapeutic trough attainment using adjusted body weight (AdjBW)-based and total body weight (TBW)-based dosing in overweight and obese patients. Of the 130 patients included, 45 patients received TBW-based dosing and 85 patients received AdjBW-based dosing. Therapeutic trough attainment was significantly improved with AdjBW-based dosing compared to TBW-based dosing (64.7% versus 46.7%; 0.047).
本回顾性单中心研究纳入了一组接受伏立康唑治疗并在治疗过程中测量稳态谷浓度的成年患者，评估了超重和肥胖患者中基于调整后体重（AdjBW）和总体重（TBW）的给药方案达到治疗谷浓度的比例。在纳入的 130 名患者中，45 名患者接受 TBW 为基础的剂量，85 名患者接受 AdjBW 为基础的剂量。与 TBW 为基础的剂量相比，AdjBW 为基础的剂量显著提高了治疗谷浓度的达标率（64.7%比 46.7%；0.047）。
