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A molecular connection hints at how a genetic risk factor drives Crohn's disease.

作者信息

Plevy Scott

出版信息

Nature. 2021 May;593(7858):201-203. doi: 10.1038/d41586-021-00979-z.

DOI:10.1038/d41586-021-00979-z
PMID:33875878
Abstract
摘要

相似文献

1
A molecular connection hints at how a genetic risk factor drives Crohn's disease.
Nature. 2021 May;593(7858):201-203. doi: 10.1038/d41586-021-00979-z.
2
Interaction Between NOD2 and Smoking in the Pathogenesis of Crohn's Disease.NOD2与吸烟在克罗恩病发病机制中的相互作用
EBioMedicine. 2017 Jul;21:49-50. doi: 10.1016/j.ebiom.2017.06.016. Epub 2017 Jun 19.
3
[Crohn's disease: genetic aspects].
Ter Arkh. 2010;82(2):66-70.
4
Non-association of Crohn's disease with NOD2 gene variants in Moroccan patients.摩洛哥患者的克罗恩病与 NOD2 基因变异无关联。
Gene. 2012 May 10;499(1):121-3. doi: 10.1016/j.gene.2011.12.045. Epub 2012 Jan 14.
5
The Nod2 gene in Crohn's disease: implications for future research into the genetics and immunology of Crohn's disease.克罗恩病中的Nod2基因：对克罗恩病遗传学和免疫学未来研究的启示
Inflamm Bowel Dis. 2001 Aug;7(3):271-5. doi: 10.1097/00054725-200108000-00014.
6
NOD1 gene E266K polymorphism is associated with disease susceptibility but not with disease phenotype or NOD2/CARD15 in Hungarian patients with Crohn's disease.在匈牙利克罗恩病患者中，NOD1基因E266K多态性与疾病易感性相关，但与疾病表型或NOD2/CARD15无关。
Dig Liver Dis. 2007 Dec;39(12):1064-70. doi: 10.1016/j.dld.2007.09.003. Epub 2007 Oct 26.
7
[Bacterial recognition of the intestinal microbial flora: an important risk factor for Crohn's disease].[肠道微生物群的细菌识别：克罗恩病的一个重要风险因素]
Med Sci (Paris). 2010 Jan;26(1):36-7. doi: 10.1051/medsci/201026136.
8
Importance of rare and private NOD2 variants in foreseeing severe disease behavior in Crohn's disease.罕见和罕见的NOD2变异在预测克罗恩病严重疾病行为中的重要性。
Am J Gastroenterol. 2011 Nov;106(11):2044-5; author reply 2045. doi: 10.1038/ajg.2011.262.
9
Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort.荷兰一个大型克罗恩病队列中疾病风险和严重程度的分子预测
Gut. 2009 Mar;58(3):388-95. doi: 10.1136/gut.2007.144865. Epub 2008 Sep 29.
10
Crohn's disease-associated Nod2 mutants reduce IL10 transcription.克罗恩病相关的Nod2突变体降低白细胞介素10的转录水平。
Nat Immunol. 2009 May;10(5):455-7. doi: 10.1038/ni0509-455.

引用本文的文献

1
JAK Inhibitor and Crohn's Disease.JAK抑制剂与克罗恩病
Biomedicines. 2025 May 29;13(6):1325. doi: 10.3390/biomedicines13061325.
2
α-Methyl-Tryptophan Inhibits SLC6A14 Expression and Exhibits Immunomodulatory Effects in Crohn's Disease.α-甲基色氨酸抑制SLC6A14表达并在克罗恩病中表现出免疫调节作用。
J Inflamm Res. 2025 Jan 24;18:1127-1145. doi: 10.2147/JIR.S495855. eCollection 2025.
3
Identification of antigen-presentation related B cells as a key player in Crohn's disease using single-cell dissecting, hdWGCNA, and deep learning.

本文引用的文献

1
Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.21 世纪全球炎症性肠病的发病率和流行率：基于人群的系统综述研究。
Lancet. 2017 Dec 23;390(10114):2769-2778. doi: 10.1016/S0140-6736(17)32448-0. Epub 2017 Oct 16.
2
IBD: Genetic differences in Crohn's disease susceptibility and outcome.炎症性肠病：克罗恩病易感性和预后的基因差异
Nat Rev Gastroenterol Hepatol. 2017 May;14(5):266-268. doi: 10.1038/nrgastro.2017.24. Epub 2017 Mar 8.
3
Nod2: A Critical Regulator of Ileal Microbiota and Crohn's Disease.
利用单细胞解析、hdWGCNA 和深度学习鉴定克罗恩病中抗原呈递相关 B 细胞的关键作用。
Clin Exp Med. 2023 Dec;23(8):5255-5267. doi: 10.1007/s10238-023-01145-7. Epub 2023 Aug 8.
Nod2：回肠微生物群和克罗恩病的关键调节因子
Front Immunol. 2016 Sep 20;7:367. doi: 10.3389/fimmu.2016.00367. eCollection 2016.
4
The zebrafish as a model to study intestinal inflammation.斑马鱼作为研究肠道炎症的模型。
Dev Comp Immunol. 2016 Nov;64:82-92. doi: 10.1016/j.dci.2016.02.020. Epub 2016 Feb 19.
5
Crohn's disease complicated by strictures: a systematic review.克罗恩病并发狭窄：系统评价。
Gut. 2013 Jul;62(7):1072-84. doi: 10.1136/gutjnl-2012-304353. Epub 2013 Apr 26.
6
Bazedoxifene: a review of its use in the treatment of postmenopausal osteoporosis.巴多昔芬：用于治疗绝经后骨质疏松症的研究进展。
Drugs. 2011 Nov 12;71(16):2193-212. doi: 10.2165/11207420-000000000-00000.
7
Function of Nod-like receptors in microbial recognition and host defense.NOD样受体在微生物识别和宿主防御中的功能。
Immunol Rev. 2009 Jan;227(1):106-28. doi: 10.1111/j.1600-065X.2008.00734.x.
8
Crohn's disease in adults: observations in a multiracial Asian population.成人克罗恩病：在一个多民族亚洲人群中的观察结果
World J Gastroenterol. 2006 Mar 7;12(9):1435-8. doi: 10.3748/wjg.v12.i9.1435.
9
The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease.NOD2基因突变对炎症性肠病发病风险及发病部位的影响
Gastroenterology. 2002 Apr;122(4):867-74. doi: 10.1053/gast.2002.32415.