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IBD: Genetic differences in Crohn's disease susceptibility and outcome.

作者信息

Mondal Kajari, Kugathasan Subra

机构信息

Emory University School of Medicine, Division of Pediatric Gastroenterology, 1760 Haygood Drive, W427, Atlanta, Georgia 30322, USA.

出版信息

Nat Rev Gastroenterol Hepatol. 2017 May;14(5):266-268. doi: 10.1038/nrgastro.2017.24. Epub 2017 Mar 8.

DOI:10.1038/nrgastro.2017.24
PMID:28270696
Abstract
摘要

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Genetic determinants associated with early age of diagnosis of IBD.与炎症性肠病早期诊断相关的遗传决定因素。
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The genetics universe of Crohn's disease and ulcerative colitis.克罗恩病和溃疡性结肠炎的遗传学研究领域。
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IBD BioResource: an open-access platform of 25 000 patients to accelerate research in Crohn's and Colitis.炎症性肠病生物资源库：一个拥有25000名患者的开放获取平台，以加速克罗恩病和结肠炎的研究。
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引用本文的文献

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A molecular connection hints at how a genetic risk factor drives Crohn's disease.
Nature. 2021 May;593(7858):201-203. doi: 10.1038/d41586-021-00979-z.

本文引用的文献

1
Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.全基因组关联研究确定了克罗恩病预后和易感性的不同遗传因素。
Nat Genet. 2017 Feb;49(2):262-268. doi: 10.1038/ng.3755. Epub 2017 Jan 9.
2
Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.通过全基因组测序探索炎症性肠病的遗传结构，发现ADCY7存在关联。
Nat Genet. 2017 Feb;49(2):186-192. doi: 10.1038/ng.3761. Epub 2017 Jan 9.
3
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
全基因组关联研究表明多种整合素基因的免疫激活与炎症性肠病有关。
Nat Genet. 2017 Feb;49(2):256-261. doi: 10.1038/ng.3760. Epub 2017 Jan 9.
4
Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway.肛周克罗恩病与远端结肠疾病、狭窄型疾病行为、炎症性肠病相关血清学及JAK-STAT信号通路中的基因变异有关。
Inflamm Bowel Dis. 2016 Apr;22(4):862-9. doi: 10.1097/MIB.0000000000000705.
5
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study.克罗恩病和溃疡性结肠炎表型的遗传决定因素：一项基因关联研究。
Lancet. 2016 Jan 9;387(10014):156-67. doi: 10.1016/S0140-6736(15)00465-1. Epub 2015 Oct 18.
6
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.关联分析确定了38个炎症性肠病的易感基因座，并突出了不同人群间共有的遗传风险。
Nat Genet. 2015 Sep;47(9):979-986. doi: 10.1038/ng.3359. Epub 2015 Jul 20.
7
Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease.多维预后风险评估确定了 IL12B 变异与克罗恩病手术之间的关联。
Inflamm Bowel Dis. 2013 Jul;19(8):1662-70. doi: 10.1097/MIB.0b013e318281f275.
8
Crohn's disease complicated by strictures: a systematic review.克罗恩病并发狭窄：系统评价。
Gut. 2013 Jul;62(7):1072-84. doi: 10.1136/gutjnl-2012-304353. Epub 2013 Apr 26.
9
CARD15/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn's disease.CARD15/NOD2基因变异与家族性发生的复杂型克罗恩病相关。
Gut. 2003 Apr;52(4):558-62. doi: 10.1136/gut.52.4.558.
10
Clinical patterns of familial inflammatory bowel disease.家族性炎症性肠病的临床模式
Gut. 1996 May;38(5):738-41. doi: 10.1136/gut.38.5.738.