Maini C L, Giordano A, Antonelli Incalzi R, Fuso L, Marchetti L
Cattedra di Medicina Nucleare, Università degli Studi, Ancona.
Radiol Med. 1988 Jun;75(6):600-3.
Mucociliary clearance can be evaluated by radionuclide techniques, but such approaches have been usually implemented only in research-oriented laboratories because of technical difficulties. A very practical radionuclide method is here presented which requires only three static acquisitions after the inhalation of a polydisperse radioaerosol produced by a commercial generator. Data processing is also very simple. The diagnostic performance of the method was tested on a study population of 10 healthy subjects and 10 patients with atrophic bronchitis; a highly significant difference between normal and pathological patients was found. Its simple implementation and diagnostic yield recommend this radionuclide method for the routine assessment of mucociliary clearance also in busy clinical-oriented laboratories.
黏液纤毛清除功能可通过放射性核素技术进行评估，但由于技术难度，此类方法通常仅在以研究为导向的实验室中实施。本文介绍了一种非常实用的放射性核素方法，该方法在吸入由商用发生器产生的多分散放射性气溶胶后仅需进行三次静态采集。数据处理也非常简单。该方法的诊断性能在10名健康受试者和10名萎缩性支气管炎患者的研究人群中进行了测试；发现正常患者和病理患者之间存在高度显著差异。其简单的实施方式和诊断效果推荐这种放射性核素方法用于繁忙的临床导向实验室中黏液纤毛清除功能的常规评估。
