Weiss T, Dorow P, Felix R
Rofo. 1980 Dec;133(6):594-602. doi: 10.1055/s-2008-1056798.
A quantitative method for study of the penetration, deposition pattern and clearance of inhaled particles (O,5-micron-99Tc-labeled human serum millimicrospheres) in the lung is described. 10 healthy subjects and 15 patients with chronic obstructive lung disease (COLD) were studied. For both groups significant differences in the mean values of two indices describing peripheral particle penetration and particle distribution homogeneity were observed. Mucociliary efficiency has been assessed by evaluating aerosol clearance rates from the whole right lung and from upper, middle, lower, perihilar and peripheral zones of the right lung field. Whereas the total lung clearance of both groups showed no marked difference, there was a statistical significant clearance delay in the patient's group upper and peripheral lung area.
本文描述了一种用于研究吸入颗粒（0.5微米 - 99锝标记的人血清毫微球）在肺部的渗透、沉积模式和清除情况的定量方法。研究了10名健康受试者和15名慢性阻塞性肺疾病（COLD）患者。在描述外周颗粒渗透和颗粒分布均匀性的两个指标的平均值方面，两组均观察到显著差异。通过评估整个右肺以及右肺野的上、中、下、肺门周围和外周区域的气溶胶清除率来评估黏液纤毛效率。虽然两组的全肺清除率没有明显差异，但患者组的上肺和外周肺区域存在统计学上显著的清除延迟。
