Department of Chemistry, Johannes Gutenberg University Mainz, Mainz 55128, Germany.
Chem Commun (Camb). 2021 May 13;57(39):4775-4778. doi: 10.1039/d1cc01428e.
Herein we demonstrate the first electrochemical synthesis protocol of symmetrical sulfamides directly from anilines and SO2 mediated by iodide. Sulfamides are an emerging functional group in drug design. Highlights are the direct use of SO2 from a stock solution and no necessity of any supporting electrolyte. Overall, the reaction has been demonstrated for 15 examples with yields up to 93%.
在此，我们展示了首个通过碘介导的苯胺和 SO2 的电化学直接合成对称磺酰胺的方法。磺酰胺是药物设计中新兴的官能团。该方法的突出特点是直接使用来自储备溶液的 SO2，且无需任何支持电解质。总体而言，该反应已经在 15 个实例中得到了证明，产率高达 93%。
