Lou Terry Shing-Bong, Kawamata Yu, Ewing Tamara, Correa-Otero Guillermo A, Collins Michael R, Baran Phil S
Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Oncology Medicinal Chemistry Department, Pfizer Pharmaceuticals, 10770 Science Center Drive, San Diego, CA 92121, USA.
Angew Chem Int Ed Engl. 2022 Sep 12;61(37):e202208080. doi: 10.1002/anie.202208080. Epub 2022 Aug 3.
Simple access to aryl sulfinates from aryl iodides and bromides is reported using an inexpensive Ni-electrocatalytic protocol. The reaction exhibits a broad scope, uses stock solution of simple SO as sulfur source, and can be scaled up in batch and recycle flow settings. The limitations of this reaction are clearly shown and put into context by benchmarking with state-of-the-art Pd-based methods.
报道了一种使用廉价镍电催化方法从芳基碘化物和溴化物简便制备芳基亚磺酸盐的方法。该反应适用范围广，使用简单的二氧化硫储备溶液作为硫源，并且可以在间歇和循环流动条件下进行放大。通过与最先进的钯基方法进行基准测试，清楚地展示了该反应的局限性并将其置于背景之中。
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