School of Materials Science and Engineering, Jilin University, Changchun, 130022, P. R. China.
Macromol Biosci. 2021 Jun;21(6):e2100055. doi: 10.1002/mabi.202100055. Epub 2021 Apr 19.
Dynamic hydrogels constructed with dynamic chemical bonds often have mechanical strength and self-healing properties. In this paper, tannic acid is combined with lysine-containing F127 through Schiff base. A series of FLaT hydrogels cross-linked by hydrogen bonds and dynamic chemical bonds is prepared, and the influence of Schiff base amount on the performance is discussed. The FLaT hydrogel exhibits reversible sol-gel transition, self-healing, injectability, and pH sensitivity. Increasing the amount of Schiff base can improve the strength, stability, and self-healing ability of the hydrogel. Owing to their low cytotoxicity, linear release pattern, and pH-controlled release rate, the FLaT hydrogels show potential use in drug delivery systems for cancer treatment.
动态水凝胶通过动态化学键构建，通常具有机械强度和自修复性能。在本文中，单宁酸通过席夫碱与含赖氨酸的 F127 结合。通过氢键和动态化学键交联制备了一系列 FLaT 水凝胶，并讨论了席夫碱用量对性能的影响。FLaT 水凝胶表现出可逆的溶胶-凝胶转变、自修复、可注射性和 pH 敏感性。增加席夫碱的用量可以提高水凝胶的强度、稳定性和自修复能力。由于其低细胞毒性、线性释放模式和 pH 控制释放速率，FLaT 水凝胶在癌症治疗的药物输送系统中具有潜在的应用价值。
