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抗菌黏附性可注射水凝胶,具有快速自修复、高拉伸和压缩性能,可用作关节皮肤伤口愈合的敷料。

Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing.

机构信息

Frontier Institute of Science and Technology, And State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

出版信息

Biomaterials. 2018 Nov;183:185-199. doi: 10.1016/j.biomaterials.2018.08.044. Epub 2018 Aug 24.


DOI:10.1016/j.biomaterials.2018.08.044
PMID:30172244
Abstract

Designing wound dressing materials with outstanding therapeutic effects, self-healing, adhesiveness and suitable mechanical property has great practical significance in healthcare, especially for joints skin wound healing. Here, we designed a kind of self-healing injectable micelle/hydrogel composites with multi-functions as wound dressing for joint skin damage. By combining the dynamic Schiff base and copolymer micelle cross-linking in one system, a series of hydrogels were prepared by mixing quaternized chitosan (QCS) and benzaldehyde-terminated PluronicF127 (PF127-CHO) under physiological conditions. The inherent antibacterial property, pH-dependent biodegradation and release behavior were investigated to confirm multi-functions of wound dressing. The hydrogel dressings showed suitable stretchable and compressive property, comparable modulus with human skin, good adhesiveness and fast self-healing ability to bear deformation. The hydrogels exhibited efficient hemostatic performance and biocompatibility. Moreover, the curcumin loaded hydrogel showed good antioxidant ability and pH responsive release profiles. In vivo experiments indicated that curcumin loaded hydrogels significantly accelerated wound healing rate with higher granulation tissue thickness and collagen disposition and upregulated vascular endothelial growth factor (VEGF) in a full-thickness skin defect model. Taken together, the antibacterial adhesive hydrogels with self-healing and good mechanical property offer significant promise as dressing materials for joints skin wound healing.

摘要

设计具有优异治疗效果、自修复、附着力和合适机械性能的伤口敷料材料在医疗保健方面具有重要的实际意义,特别是对于关节皮肤伤口愈合。在这里,我们设计了一种具有多功能的自修复注射胶束/水凝胶复合材料,可用作关节皮肤损伤的伤口敷料。通过在一个体系中结合动态席夫碱和共聚物胶束交联,在生理条件下将季铵化壳聚糖(QCS)和苯甲醛封端的泊洛沙姆 F127(PF127-CHO)混合制备了一系列水凝胶。研究了水凝胶的固有抗菌性能、pH 依赖性生物降解和释放行为,以确认伤口敷料的多功能性。水凝胶敷料表现出适宜的拉伸和压缩性能、与人皮肤相当的模量、良好的附着力和快速的自修复能力以承受变形。水凝胶表现出高效的止血性能和生物相容性。此外,负载姜黄素的水凝胶显示出良好的抗氧化能力和 pH 响应释放特性。体内实验表明,负载姜黄素的水凝胶在全层皮肤缺损模型中显著加速了伤口愈合速度,具有更高的肉芽组织厚度和胶原排列,并上调了血管内皮生长因子(VEGF)。综上所述,具有抗菌性、粘附性、自修复性和良好机械性能的水凝胶为关节皮肤伤口愈合提供了有前景的敷料材料。

相似文献

[1]
Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing.

Biomaterials. 2018-8-24

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